Nowomiejska Katarzyna, Brzozowska Agnieszka, Koss Michael J, Weleber Richard G, Schiefer Ulrich, Rejdak Konrad, Juenemann Anselm G, Maciejewski Ryszard, Rejdak Robert
a Department of General Ophthalmology , Medical University in Lublin , Poland.
b Department of Mathematics and Medical Biostatistics , Medical University , Lublin , Poland.
Curr Eye Res. 2016 Jul;41(7):993-8. doi: 10.3109/02713683.2015.1079328. Epub 2015 Oct 15.
To assess quantitatively the natural course of the visual field (VF) loss in patients with retinitis pigmentosa (RP) during 2-year period of observation.
VFs were obtained by semi-automated kinetic perimetry (SKP) during four examinations of 16 patients suffering from RP. Three stimulus conditions (V4e, III4e and I4e) with a constant stimulus angular velocity of 3°/s were used to assess the hill of vision in both eyes of each patient. The area of each isopter was measured in square degrees and corrected for the individual reaction time (RT).
There were four patients with mild restriction of VF, six with ring scotomas and six with advanced concentric constrictions of VF. Only I4e isopter area decreased significantly from the first to the last session (p = 0.006), the difference was 154 deg(2) being 13% of initial isopter area. The difference was not significant for V4e and III4e isopters. RT values did not differ significantly between four sessions.
Only I4e isopter's area was decreased significantly during two years of observation. SKP provides a method of assessment of progression of the VF loss in patients suffering from RP by measurement of the isopters' area over time.
定量评估视网膜色素变性（RP）患者在2年观察期内视野（VF）丧失的自然病程。
通过半自动动态视野计（SKP）对16例RP患者进行4次检查，获取视野数据。采用三种刺激条件（V4e、III4e和I4e），刺激角速度恒定为3°/秒，评估每位患者双眼的视岛。每个等视线的面积以平方度为单位进行测量，并针对个体反应时间（RT）进行校正。
4例患者视野轻度受限，6例有环形暗点，6例有晚期同心性视野缩窄。仅I4e等视线面积从第一次检查到最后一次检查显著减小（p = 0.006），差值为154度²，占初始等视线面积的13%。V4e和III4e等视线的差异不显著。四次检查之间的RT值无显著差异。
在两年观察期内，仅I4e等视线面积显著减小。SKP通过随时间测量等视线面积，提供了一种评估RP患者视野丧失进展的方法。
