Çelik Tanju, Güler Ekrem, Berksoy Emel Ataş, Sorguç Yelda, Arslan Nur
Dr. Behçet Uz Çocuk Hastanesi, Çocuk Acil Bölümü, İzmir, Türkiye.
Turkiye Parazitol Derg. 2015 Sep;39(3):205-8. doi: 10.5152/tpd.2015.3963.
Mean platelet volume (MPV) is a marker of platelet activation, which is a determinant of inflammation. The first aim of the present study was to investigate the MPV levels in children with amebiasis and compare the MPV levels with healthy controls. The second aim of this study was to evaluate the relationship between MPV and other acute phase reactants.
Seventy six patients with amebic gastroenteritis (mean age 2.64 ± 0.23 years) and 53 healthy controls (mean age 2.35 ± 0.28 years) were enrolled in the study. Entamoeba histolytica was determined in stool using rapid antigen test.
Complete blood count and C-reactive protein (CRP) levels were assessed for all children. MPV levels of patients with amebiasis were significantly higher than those of control children (8.79 ± 0.09 vs. 7.87 ± 0.09 fL, p = 0.000). Leukocyte and eosinophil counts, C-reactive protein and creatinine levels of the patients were higher than controls. Leukocyte count was positively correlated with MPV (r = 0.192, p < 0.05), platelet count (r = 0.278, p < 0.01), and CRP level (r = 0.205, p < 0.05).
In this MPV levels were significantly higher in children with amebiasis compared to controls. MPV can be used as an acute phase reactant in children with Entamoeba histolytica gastroenteritis.
平均血小板体积（MPV）是血小板活化的标志物，而血小板活化是炎症的一个决定因素。本研究的首要目的是调查阿米巴病患儿的MPV水平，并将其与健康对照者的MPV水平进行比较。本研究的第二个目的是评估MPV与其他急性期反应物之间的关系。
本研究纳入了76例阿米巴性胃肠炎患儿（平均年龄2.64±0.23岁）和53名健康对照者（平均年龄2.35±0.28岁）。采用快速抗原检测法在粪便中检测溶组织内阿米巴。
对所有儿童进行了全血细胞计数和C反应蛋白（CRP）水平评估。阿米巴病患者的MPV水平显著高于对照儿童（8.79±0.09 vs. 7.87±0.09 fL，p = 0.000）。患者的白细胞和嗜酸性粒细胞计数、C反应蛋白和肌酐水平均高于对照组。白细胞计数与MPV呈正相关（r = 0.192，p < 0.05）、血小板计数（r = 0.278，p < 0.01）和CRP水平（r = 0.205，p < 0.05）。
在本研究中，阿米巴病患儿的MPV水平显著高于对照组。MPV可作为溶组织内阿米巴性胃肠炎患儿的一种急性期反应物。
