Chang Connie Y, Goldstein Elisabeth, Agarwal Nitin, Swan Kenneth G
Department of Anesthesia, Rutgers New Jersey Medical School, Newark, NJ, 07101-1709, USA.
Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA.
BMC Anesthesiol. 2015 Oct 16;15:149. doi: 10.1186/s12871-015-0128-3.
The first true demonstration of ether as an inhalation anesthetic was on October 16, 1846 by William T.G. Morton, a Boston dentist. Ether has been replaced completely by newer inhalation agents and open drop delivery systems have been exchanged for complicated vaporizers and monitoring systems. Anesthesia in the developing world, however, where lack of financial stability has halted the development of the field, still closely resembles primitive anesthetics.
In areas where resources are scarce, patients are often not given supplemental intraoperative analgesia. While halothane provides little analgesia, ether provides excellent intra-operative pain control that can extend for several hours into the postoperative period. An important barrier to the widespread use of ether is availability. With decreasing demand, production of the inexpensive inhalation agent has fallen. Ether is inexpensive to manufacture, and encouraging increased production at a local level would help developing nations to cut costs and become more self-sufficient.
1846年10月16日,波士顿牙医威廉·T·G·莫顿首次成功展示了乙醚作为吸入式麻醉剂的效用。如今,乙醚已完全被新型吸入式麻醉剂所取代,开放式滴注给药系统也已被复杂的蒸发器和监测系统所替代。然而,在发展中世界,由于经济不稳定阻碍了该领域的发展,麻醉方式仍与原始麻醉方法极为相似。
在资源匮乏的地区,患者术中往往无法获得辅助镇痛。虽然氟烷几乎无法提供镇痛效果,但乙醚却能在术中提供出色的疼痛控制,且这种效果可延续至术后数小时。乙醚广泛应用的一个重要障碍是其可得性。随着需求的减少,这种廉价吸入剂的产量也在下降。乙醚生产成本低廉,鼓励在当地增加产量将有助于发展中国家降低成本并实现更大程度的自给自足。