Suppr超能文献

发展中世界的乙醚:重新审视一种被摒弃的药剂。

Ether in the developing world: rethinking an abandoned agent.

作者信息

Chang Connie Y, Goldstein Elisabeth, Agarwal Nitin, Swan Kenneth G

机构信息

Department of Anesthesia, Rutgers New Jersey Medical School, Newark, NJ, 07101-1709, USA.

Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA.

出版信息

BMC Anesthesiol. 2015 Oct 16;15:149. doi: 10.1186/s12871-015-0128-3.

Abstract

BACKGROUND

The first true demonstration of ether as an inhalation anesthetic was on October 16, 1846 by William T.G. Morton, a Boston dentist. Ether has been replaced completely by newer inhalation agents and open drop delivery systems have been exchanged for complicated vaporizers and monitoring systems. Anesthesia in the developing world, however, where lack of financial stability has halted the development of the field, still closely resembles primitive anesthetics.

DISCUSSION

In areas where resources are scarce, patients are often not given supplemental intraoperative analgesia. While halothane provides little analgesia, ether provides excellent intra-operative pain control that can extend for several hours into the postoperative period. An important barrier to the widespread use of ether is availability. With decreasing demand, production of the inexpensive inhalation agent has fallen. Ether is inexpensive to manufacture, and encouraging increased production at a local level would help developing nations to cut costs and become more self-sufficient.

摘要

背景

1846年10月16日,波士顿牙医威廉·T·G·莫顿首次成功展示了乙醚作为吸入式麻醉剂的效用。如今,乙醚已完全被新型吸入式麻醉剂所取代,开放式滴注给药系统也已被复杂的蒸发器和监测系统所替代。然而,在发展中世界,由于经济不稳定阻碍了该领域的发展,麻醉方式仍与原始麻醉方法极为相似。

讨论

在资源匮乏的地区,患者术中往往无法获得辅助镇痛。虽然氟烷几乎无法提供镇痛效果,但乙醚却能在术中提供出色的疼痛控制,且这种效果可延续至术后数小时。乙醚广泛应用的一个重要障碍是其可得性。随着需求的减少,这种廉价吸入剂的产量也在下降。乙醚生产成本低廉,鼓励在当地增加产量将有助于发展中国家降低成本并实现更大程度的自给自足。

相似文献

5

引用本文的文献

1
The evolution of the meniscus: Where surgical advancements meet translational research.半月板的演变:手术进展与转化研究的交汇之处。
Osteoarthr Cartil Open. 2025 Aug 21;7(4):100666. doi: 10.1016/j.ocarto.2025.100666. eCollection 2025 Dec.
7
Parahydrogen-Induced Polarization of Diethyl Ether Anesthetic.氘代氢化引起的乙醚麻醉剂的极化。
Chemistry. 2020 Oct 27;26(60):13621-13626. doi: 10.1002/chem.202002528. Epub 2020 Sep 17.

本文引用的文献

2
Two hundred years of surgery.两百年的外科手术史。
N Engl J Med. 2012 May 3;366(18):1716-23. doi: 10.1056/NEJMra1202392.
5
Halothane hepatitis in Iran: a review of 59 cases.伊朗的氟烷性肝炎:59例病例回顾
World J Gastroenterol. 2008 Sep 14;14(34):5322-6. doi: 10.3748/wjg.14.5322.
6
Pediatric anesthesia in developing countries.发展中国家的儿科麻醉
Curr Opin Anaesthesiol. 2007 Jun;20(3):204-10. doi: 10.1097/ACO.0b013e3280c60c78.

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验