Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
Department of Nursing, China Medical University Hospital, Taichung, Taiwan.
Food Nutr Res. 2015 Oct 15;59:29018. doi: 10.3402/fnr.v59.29018. eCollection 2015.
Obesity is a chronic metabolic disorder associated with an increase in adipogenesis and often accompanied with fatty liver disease.
In this study, we investigated the anti-obesity effects of Hibiscus sabdariffa water extract (HSE) in vivo.
Eight-weeks-old male mice were divided into six groups (n=8 per group) and were fed either normal feed, a high fat diet (HFD), HFD supplemented with different concentrations of HSE, or HFD supplemented with anthocyanin. After 10 weeks of feeding, all the blood and livers were collected for further analysis.
Mesocricetus auratus hamster fed with a high-fat diet developed symptoms of obesity, as determined from their body weight change and from their plasma lipid levels. Meanwhile, HSE treatment reduced fat accumulation in the livers of hamsters fed with HFD in a concentration-dependent manner. Administration of HSE reduced the levels of liver cholesterol and triglycerides, which were elevated by HFD. Analysis of the effect of HSE on paraoxonase 1, an antioxidant liver enzyme, revealed that HSE potentially regulates lipid peroxides and protects organs from oxidation-associated damage. The markers of liver damage such as serum alanine aminotransferase and aspartate aminotransferase levels that were elevated by HFD were also reduced on HSE treatment. The effects of HSE were as effective as treatment with anthocyanin; therefore the anthocyanins present in the HSE may play a crucial role in the protection established against HFD-induced obesity.
In conclusion HSE administration constitutes an effective and viable treatment strategy against the development and consequences of obesity.
肥胖是一种与脂肪生成增加相关的慢性代谢紊乱，常伴有脂肪肝疾病。
本研究旨在体内研究洛神花水提取物（HSE）的抗肥胖作用。
将 8 周龄雄性小鼠分为六组（每组 8 只），分别喂食正常饲料、高脂肪饮食（HFD）、HFD 补充不同浓度的 HSE 或 HFD 补充花青素。喂养 10 周后，收集所有血液和肝脏进行进一步分析。
高脂饮食喂养的金黄地鼠出现肥胖症状，表现为体重变化和血浆脂质水平。同时，HSE 处理以浓度依赖的方式减少 HFD 喂养的地鼠肝脏脂肪堆积。HSE 降低了 HFD 升高的肝胆固醇和甘油三酯水平。分析 HSE 对抗氧化肝酶对氧磷酶 1 的影响表明，HSE 可能调节脂质过氧化物并保护器官免受氧化相关损伤。HFD 升高的血清丙氨酸氨基转移酶和天冬氨酸氨基转移酶等肝损伤标志物也在 HSE 治疗后降低。HSE 的作用与花青素治疗一样有效；因此，HSE 中存在的花青素可能在预防 HFD 诱导的肥胖方面发挥关键作用。
总之，HSE 给药构成了针对肥胖发生和后果的有效可行的治疗策略。
