Institute of Medicine, Chung-Shan Medical University, Taiwan.
Food Funct. 2014 Apr;5(4):734-9. doi: 10.1039/c3fo60495k. Epub 2014 Feb 19.
Obesity is associated with a great diversity of diseases including non-alcoholic fatty liver disease. Our previous report suggested that Hibiscus sabdariffa extracts (HSE) had a metabolic-regulating and liver-protecting potential. In this study, we performed a clinical trial to further confirm the effect of HSE. Subjects with a BMI ≧ 27 and aged 18-65, were randomly divided into control (n = 17) and HSE-treated (n = 19) groups, respectively, for 12 weeks. Our data showed that consumption of HSE reduced body weight, BMI, body fat and the waist-to-hip ratio. Serum free fatty acid (FFA) was lowered by HSE. Anatomic changes revealed that HSE improved the illness of liver steatosis. Ingestion of HSE was well tolerated and there was no adverse effect during the trial. No alteration was found for serum α-amylase and lipase. The clinical effect should mainly be attributed to the polyphenols of HSE, since composition analysis showed that branched chain-amino acids, which is associated with obesity, is not obviously high. In conclusion, consumption of HSE reduced obesity, abdominal fat, serum FFA and improved liver steatosis. HSE could act as an adjuvant for preventing obesity and non-alcoholic fatty liver.
肥胖与多种疾病相关，包括非酒精性脂肪性肝病。我们之前的报告表明，洛神花提取物（HSE）具有代谢调节和肝脏保护作用。在这项研究中，我们进行了一项临床试验，以进一步证实 HSE 的效果。BMI≥27 且年龄在 18-65 岁之间的受试者被随机分为对照组（n=17）和 HSE 治疗组（n=19），分别进行 12 周的治疗。我们的数据显示，HSE 的摄入降低了体重、BMI、体脂肪和腰臀比。血清游离脂肪酸（FFA）也因 HSE 而降低。解剖学变化显示，HSE 改善了肝脂肪变性的疾病。HSE 的摄入耐受良好，在试验过程中没有不良反应。血清α-淀粉酶和脂肪酶没有变化。临床效果主要归因于 HSE 的多酚，因为成分分析表明，与肥胖相关的支链氨基酸并不明显高。总之，HSE 的摄入降低了肥胖、腹部脂肪、血清 FFA 并改善了肝脂肪变性。HSE 可以作为预防肥胖和非酒精性脂肪性肝病的辅助剂。
