• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

用于科学研究的动物的疼痛管理:加拿大科学家和兽医的观点。

Pain Management for Animals Used in Science: Views of Scientists and Veterinarians in Canada.

作者信息

Fenwick Nicole, Duffus Shannon E G, Griffin Gilly

机构信息

Canadian Council on Animal Care (CCAC), 190 O'Connor St., Suite 800, Ottawa, ON, K2P 2R3, Canada.

出版信息

Animals (Basel). 2014 Aug 4;4(3):494-514. doi: 10.3390/ani4030494.

DOI:10.3390/ani4030494
PMID:26480320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4494316/
Abstract

To explore the challenges and opportunities for pain management for animals used in research an interview study with 9 veterinarians, 3 veterinarian-scientists and 9 scientists, all engaged in animal-based studies in Canada, was carried out. Our broader aim was to contribute to further discussion of how pain can be minimized for animals used in science. Diverse views were identified regarding the ease of recognizing when animals are in pain and whether animals hide pain. Evidence of inconsistencies in pain management across laboratories, institutions and species were also identified. Clarification of the interactions between scientific objectives and pain management are needed, as well as a stronger evidence base for pain management approaches. Detailed examination of pain management for individual invasive animal models may be useful, and may support the development of model-specific pain management protocols.

摘要

为探讨用于研究的动物疼痛管理面临的挑战与机遇,我们对9名兽医、3名兽医科学家和9名科学家进行了访谈研究,他们均在加拿大从事基于动物的研究。我们更广泛的目标是促进关于如何将用于科学研究的动物疼痛降至最低的进一步讨论。在动物疼痛的识别难易程度以及动物是否会隐藏疼痛方面,我们发现了不同的观点。我们还发现了各实验室、机构和物种在疼痛管理方面存在不一致的证据。需要明确科学目标与疼痛管理之间的相互作用,同时也需要一个更有力的疼痛管理方法证据基础。对单个侵入性动物模型的疼痛管理进行详细研究可能会有所帮助,并可能支持制定特定模型的疼痛管理方案。

相似文献

1
Pain Management for Animals Used in Science: Views of Scientists and Veterinarians in Canada.用于科学研究的动物的疼痛管理:加拿大科学家和兽医的观点。
Animals (Basel). 2014 Aug 4;4(3):494-514. doi: 10.3390/ani4030494.
2
Attitudes towards perception and management of pain in rabbits and guinea pigs by a sample of veterinarians in New Zealand.新西兰部分兽医对兔和豚鼠疼痛感知与管理的态度。
N Z Vet J. 2011 Nov;59(6):305-10. doi: 10.1080/00480169.2011.609477.
3
Attitudes and concerns of French veterinarians towards pain and analgesia in dogs and cats.法国兽医对犬猫疼痛与镇痛的态度及关注
Vet Anaesth Analg. 2004 Jul;31(3):154-63. doi: 10.1111/j.1467-2987.2004.00175.x.
4
Evaluation of a welfare assessment tool to examine practices for preventing, recognizing, and managing pain at companion-animal veterinary clinics.评估一种福利评估工具,以检查伴侣动物兽医诊所预防、识别和管理疼痛的实践情况。
Can J Vet Res. 2017 Oct;81(4):270-279.
5
Recognizing and assessing pain, suffering and distress in laboratory animals: a survey of current practice in the UK with recommendations.识别与评估实验动物的疼痛、痛苦和苦恼:英国当前实践调查及建议
Lab Anim. 2002 Oct;36(4):378-95. doi: 10.1258/002367702320389044.
6
A conceptual framework for understanding the perspectives on the causes of the science-practice gap in ecology and conservation.理解生态学和保护学中科学实践差距成因观点的概念框架。
Biol Rev Camb Philos Soc. 2018 May;93(2):1032-1055. doi: 10.1111/brv.12385. Epub 2017 Nov 20.
7
Training strategies for laboratory animal veterinarians: challenges and opportunities.实验动物兽医的培训策略:挑战与机遇
ILAR J. 2007;48(2):143-55. doi: 10.1093/ilar.48.2.143.
8
Challenges with Assessing and Treating Pain in Research Primates: A Focused Survey and Literature Review.研究灵长类动物疼痛评估与治疗的挑战:一项重点调查与文献综述
Animals (Basel). 2022 Sep 5;12(17):2304. doi: 10.3390/ani12172304.
9
Pain and Laboratory Animals: Publication Practices for Better Data Reproducibility and Better Animal Welfare.疼痛与实验动物:为实现更好的数据可重复性和更好的动物福利的出版规范
PLoS One. 2016 May 12;11(5):e0155001. doi: 10.1371/journal.pone.0155001. eCollection 2016.
10
Effect of question design on dietary information solicited during veterinarian-client interactions in companion animal practice in Ontario, Canada.问题设计对加拿大安大略省伴侣动物诊疗中兽医与客户互动期间所获取的饮食信息的影响。
J Am Vet Med Assoc. 2015 Jun 1;246(11):1203-14. doi: 10.2460/javma.246.11.1203.

引用本文的文献

1
Reporting practices of anesthetic and analgesic use in rodent orthopedic research.报告啮齿动物骨科研究中麻醉和镇痛使用的情况。
Sci Rep. 2024 Nov 18;14(1):26225. doi: 10.1038/s41598-024-76750-x.
2
Effectiveness of two extended-release buprenorphine formulations during postoperative period in neonatal rats.两种缓释丁丙诺啡制剂在新生大鼠术后期间的效果。
PLoS One. 2022 Oct 17;17(10):e0276327. doi: 10.1371/journal.pone.0276327. eCollection 2022.
3
Challenges with Assessing and Treating Pain in Research Primates: A Focused Survey and Literature Review.研究灵长类动物疼痛评估与治疗的挑战:一项重点调查与文献综述
Animals (Basel). 2022 Sep 5;12(17):2304. doi: 10.3390/ani12172304.
4
Clinical Management of Pain in Rodents.啮齿动物疼痛的临床管理
Comp Med. 2019 Dec 1;69(6):468-489. doi: 10.30802/AALAS-CM-19-000048. Epub 2019 Dec 10.

本文引用的文献

1
Improving the translation of analgesic drugs to the clinic: animal models of neuropathic pain.改善镇痛药在临床中的转化:神经病理性疼痛的动物模型。
Br J Pharmacol. 2014 Jun;171(12):2951-63. doi: 10.1111/bph.12645.
2
Comparative effects of vasectomy surgery and buprenorphine treatment on faecal corticosterone concentrations and behaviour assessed by manual and automated analysis methods in C57 and C3H mice.比较输精管切除术和丁丙诺啡治疗对 C57 和 C3H 小鼠粪便皮质酮浓度和行为的影响,采用手动和自动分析方法评估。
PLoS One. 2013 Sep 30;8(9):e75948. doi: 10.1371/journal.pone.0075948. eCollection 2013.
3
How to improve housing conditions of laboratory animals: the possibilities of environmental refinement.如何改善实验动物的住房条件:环境精细化的可能性。
Vet J. 2013 Jan;195(1):24-32. doi: 10.1016/j.tvjl.2012.09.023. Epub 2012 Nov 3.
4
Postoperative pain and perioperative analgesic administration in dogs: practices, attitudes and beliefs of Queensland veterinarians.犬类术后疼痛与围手术期镇痛药物的使用:昆士兰兽医的实践、态度与看法
Aust Vet J. 2012 May;90(5):186-93. doi: 10.1111/j.1751-0813.2012.00901.x.
5
Using the Mouse Grimace Scale to reevaluate the efficacy of postoperative analgesics in laboratory mice.使用小鼠面部表情评分法重新评估实验小鼠术后镇痛药的疗效。
J Am Assoc Lab Anim Sci. 2012 Jan;51(1):42-9.
6
Pain in laboratory animals: the ethical and regulatory imperatives.实验动物的疼痛:伦理与监管要求
PLoS One. 2011;6(9):e21578. doi: 10.1371/journal.pone.0021578. Epub 2011 Sep 7.
7
The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions.大鼠苦脸评分:一种通过面部表情在实验室大鼠中量化疼痛的部分自动化方法。
Mol Pain. 2011 Jul 29;7:55. doi: 10.1186/1744-8069-7-55.
8
Analgesic effects of tramadol, tramadol-gabapentin, and buprenorphine in an incisional model of pain in rats (Rattus norvegicus).曲马多、曲马多-加巴喷丁和丁丙诺啡在大鼠(褐家鼠)切口痛模型中的镇痛作用。
J Am Assoc Lab Anim Sci. 2011 Mar;50(2):192-7.
9
Are we looking in the wrong place? Implications for behavioural-based pain assessment in rabbits (Oryctolagus cuniculi) and beyond?我们是否找错了地方?对兔(Oryctolagus cuniculi)及其他动物的基于行为的疼痛评估的启示?
PLoS One. 2011 Mar 15;6(3):e13347. doi: 10.1371/journal.pone.0013347.
10
Reported analgesic administration to rabbits undergoing experimental surgical procedures.报告了在进行实验性手术的兔子身上使用的镇痛药物。
BMC Vet Res. 2011 Feb 21;7:12. doi: 10.1186/1746-6148-7-12.