Chen Ridao, Duan Ruigang, Wei Yannan, Zou Jianhua, Li Junwei, Liu Xiaoyue, Wang Haiyan, Guo Ying, Li Qiuhong, Dai Jungui
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050, PR China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050, PR China; Institute of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China.
Fitoterapia. 2015 Dec;107:77-84. doi: 10.1016/j.fitote.2015.10.005. Epub 2015 Oct 19.
A chemical investigation of callus cultures of Dysosma versipellis led to the isolation of five new flavonol dimers, dysoverines A-E (1-5), together with 12 known compounds (6-17). The structures of new compounds were determined by the extensive spectroscopic data analyses. The biosynthetic pathway of the new compounds was proposed to involve O-methylation, prenylation, and Diels-Alder cycloaddition, which successively occurred in cultured plant cells. Compounds 1-17 exhibited in vitro neuraminidase inhibitory activities with the IC50 values of 31.0-93.9μM.
对八角莲愈伤组织培养物进行化学研究，从中分离出5个新的黄酮醇二聚体，即八角莲素A - E（1 - 5），以及12个已知化合物（6 - 17）。通过广泛的光谱数据分析确定了新化合物的结构。推测新化合物的生物合成途径涉及O - 甲基化、异戊烯基化和狄尔斯 - 阿尔德环加成反应，这些反应在培养的植物细胞中依次发生。化合物1 - 17表现出体外神经氨酸酶抑制活性，IC50值为31.0 - 93.9μM。
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