从和的根和根茎中分离得到的木脂素及其细胞毒性活性。

Lignans from the Roots and Rhizomes of and Their Cytotoxic Activities.

机构信息

Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China.

School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.

出版信息

Molecules. 2023 Mar 24;28(7):2909. doi: 10.3390/molecules28072909.

DOI:10.3390/molecules28072909

PMID:37049673

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10095701/

Abstract

One new dibenzyltyrolactone lignan dysoslignan A (), three new arylnaphthalide lignans dysoslignan B-C (-), along with fourteen known metabolites (-), were isolated from the roots and rhizomes of . Their structures and stereochemistry were determined from analysis of NMR spectroscopic and circular dichroism (CD) data. Compound represents the first report of naturally occurring arylnaphthalide lignan triglycoside. The cytotoxic activities of all isolated compounds were evaluated against A-549 and SMMC-7721 cell lines. Compounds - and - were more toxic than cisplatin in two tumor cell lines. This investigation clarifies the potential effective substance basis of in tumor treatment.

摘要

从根和根茎中分离得到一个新的二苄基四氢呋喃木脂素 dysoslignan A (), 三个新的芳基萘丙素木脂素 dysoslignan B-C (-), 以及 14 个已知代谢物 (-)。通过 NMR 光谱和圆二色性 (CD) 数据分析确定了它们的结构和立体化学。化合物代表了天然存在的芳基萘丙素木脂素三糖苷的首次报道。所有分离化合物的细胞毒性活性均针对 A-549 和 SMMC-7721 细胞系进行了评估。化合物 - 和 - 在两种肿瘤细胞系中的毒性均大于顺铂。本研究阐明了治疗肿瘤的潜在有效物质基础。