早产儿视网膜病变：加拿大新生儿重症监护病房的风险因素及变异性
Retinopathy of prematurity: Risk factors and variability in Canadian neonatal intensive care units.
作者信息
Thomas K, Shah P S, Canning R, Harrison A, Lee S K, Dow K E
机构信息
Department of Pediatrics, Kingston General Hospital, Kingston, Ontario, Canada.
Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
出版信息
J Neonatal Perinatal Med. 2015;8(3):207-14. doi: 10.3233/NPM-15814128.
OBJECTIVE
To identify predictors of severe retinopathy of prematurity (ROP) in a large population-based cohort and to examine risk-adjusted variations across units.
STUDY DESIGN
Retrospective analysis of Canadian Neonatal Network data on neonates with birth weight <1500 g who were screened for ROP between 2003 and 2010. Characteristics of infants with and without ROP were compared and a risk-adjusted model for severe ROP was developed. Rates of severe ROP were compared between sites.
RESULTS
1163 of 9187 (12.7%) infants developed severe ROP. Lower gestational age, male sex, small for gestational age, patent ductus arteriosus, late onset sepsis, more than two blood transfusions, inotrope use, and outborn status were associated with an increased risk of severe ROP. Severe ROP rates varied significantly between units.
CONCLUSION
Younger, smaller and sicker male infants had higher adjusted risks of severe ROP and rates varied significantly among sites.
目的
在一个基于人群的大型队列中确定早产儿视网膜病变（ROP）严重程度的预测因素，并研究各单位之间经风险调整后的差异。
研究设计
对加拿大新生儿网络中2003年至2010年间出生体重<1500 g且接受ROP筛查的新生儿数据进行回顾性分析。比较了发生和未发生ROP的婴儿的特征，并建立了严重ROP的风险调整模型。比较了各研究点之间严重ROP的发生率。
结果
9187例婴儿中有1163例（12.7%）发生严重ROP。孕周较小、男性、小于胎龄儿、动脉导管未闭、晚发性败血症、输血超过两次、使用血管活性药物以及出生于外院与严重ROP风险增加相关。各单位之间严重ROP的发生率差异显著。
结论
年龄较小、体型较小且病情较重的男婴发生严重ROP的调整后风险较高，且各研究点之间的发生率差异显著。
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