Yu Xin, Li Zheng
Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100042, China.
Department of Orthopedics Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100042, China.
Tumour Biol. 2016 Jan;37(1):57-60. doi: 10.1007/s13277-015-4273-6. Epub 2015 Oct 20.
TARBP2 is a RNA-binding protein (RBP) involved in miRNA processing and maturation. TARBP2 plays significant roles in many biological and pathological conditions, including viral expression of HIV-1, microsatellite instability, cancer stem cell properties, and tumor progression. Overexpression of TARBP2 was observed in many cancers such as prostate cancer, cutaneous malignant melanoma, and adrenocortical carcinoma. In addition, TARBP2 was also found to be downregulated in some cancers including colorectal cancer, gastric cancer, Ewing sarcoma, and upper urinary tract urothelial carcinoma. Therefore, whether TARBP2 functions as the tumor suppressor or tumor promoter is conflicting. In the present review, we provide an overview of current knowledge concerning the role of TARBP2 in tumor development and progression.
TARBP2是一种参与微小RNA（miRNA）加工和成熟的RNA结合蛋白（RBP）。TARBP2在许多生物学和病理状况中发挥重要作用，包括HIV-1的病毒表达、微卫星不稳定性、癌症干细胞特性和肿瘤进展。在许多癌症中观察到TARBP2过表达，如前列腺癌、皮肤恶性黑色素瘤和肾上腺皮质癌。此外，在包括结直肠癌、胃癌、尤因肉瘤和上尿路尿路上皮癌在内的一些癌症中也发现TARBP2表达下调。因此，TARBP2是作为肿瘤抑制因子还是肿瘤促进因子发挥作用存在争议。在本综述中，我们概述了有关TARBP2在肿瘤发生和进展中作用的当前知识。
