Floersheim G L
Z Hautkr. 1989 Jan 15;64(1):41-8.
Frailty and brittleness of the finger nails is frequently seen, particularly in women. In veterinary medicine, it has been documented that defect hooves of horses or claws of swines respond well to oral application of biotin. Accordingly, we studied the effect of biotin on human dystrophic finger nails, a keratin structure as well. 71 patients were treated with a daily oral dose of biotin of 2.5 mg. Out of the 45 cases which finally could be evaluated, 41 (91%) showed definite improvement with firmer and harder finger nails after an average treatment of 5.5 +/- 2.3 months. In 4 of the 45 patients (9%), the improvement was questionable. None of the patients considered the treatment altogether ineffective. We conclude that biotin in most of the cases provides an effective therapy also for human patients with brittle nails.
指甲脆弱易碎的情况很常见，尤其是在女性中。在兽医学中，有记录表明马的蹄部缺陷或猪的爪子在口服生物素后反应良好。因此，我们研究了生物素对角化结构——人类营养不良指甲的影响。71名患者每日口服2.5毫克生物素进行治疗。在最终可评估的45例病例中，平均治疗5.5±2.3个月后，41例（91%）指甲变得更坚固、更硬，显示出明显改善。45例患者中有4例（9%）改善情况存疑。没有患者认为治疗完全无效。我们得出结论，在大多数情况下，生物素对患有脆甲症的人类患者也提供了有效的治疗方法。
