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口服特定的生物活性胶原蛋白肽可促进指甲生长并减轻指甲脆弱症状。

Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails.

作者信息

Hexsel Doris, Zague Vivian, Schunck Michael, Siega Carolina, Camozzato Fernanda O, Oesser Steffen

机构信息

Brazilian Center for Studies in Dermatology, Porto Algre, Brazil.

Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

出版信息

J Cosmet Dermatol. 2017 Dec;16(4):520-526. doi: 10.1111/jocd.12393. Epub 2017 Aug 8.

DOI:10.1111/jocd.12393
PMID:28786550
Abstract

BACKGROUND

Brittle nail syndrome is a common problem among women and refers to nails that exhibit surface roughness, raggedness, and peeling.

AIM

The goal of this study was to investigate whether daily oral supplementation with collagen peptides alleviates the symptoms of brittle nails and improves nail growth rate.

METHODS

In this open-label, single-center trial, 25 participants took 2.5 g of specific bioactive collagen peptides (BCP, VERISOL ) once daily for 24 weeks followed by a 4-week off-therapy period. Nail growth rate and the frequency of cracked and/or chipped nails as well as an evaluation of symptoms and global clinical improvement score of brittle nails were assessed by a physician during treatment and 4 weeks after discontinuation.

RESULTS

Bioactive collagen peptides treatment promoted an increase of 12% nail growth rate and a decrease of 42% in the frequency of broken nails. Additionally, 64% of participants achieved a global clinical improvement in brittle nails, and 88% of participants experienced an improvement 4 weeks post-treatment. The majority of participants (80%) agreed that the use of BCP improved their nails' appearance, and were completely satisfied with the performance of the treatment.

CONCLUSIONS

This study demonstrated that the daily ingestion of BCP increased nail growth and improved brittle nails in conjunction with a notable decrease in the frequency of broken nails.

摘要

背景

脆甲综合征是女性常见的问题,指的是指甲表面粗糙、参差不齐且易剥落。

目的

本研究的目的是调查每日口服胶原蛋白肽是否能缓解脆甲症状并提高指甲生长速度。

方法

在这项开放标签的单中心试验中,25名参与者每天服用2.5克特定的生物活性胶原蛋白肽(BCP,VERISOL),持续24周,随后有4周的停药期。在治疗期间和停药后4周,由医生评估指甲生长速度、指甲开裂和/或破损的频率,以及脆甲症状评估和整体临床改善评分。

结果

生物活性胶原蛋白肽治疗使指甲生长速度提高了12%,指甲破损频率降低了42%。此外,64%的参与者脆甲症状得到整体临床改善,88%的参与者在治疗后4周症状有所改善。大多数参与者(80%)认为使用BCP改善了指甲外观,并对治疗效果完全满意。

结论

本研究表明,每日摄入BCP可促进指甲生长,改善脆甲症状,同时显著降低指甲破损频率。

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