Janahmadi Z, Nekooeian A A, Mozafari M
Cardiovascular Pharmacology Research Lab, Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
Res Pharm Sci. 2015 Mar-Apr;10(2):125-33.
Some species of Allium family have been shown to offer cardioprotection in animal studies. This study aimed at examining possible role of oxidative stress in the cardioprotective effects of hydroalcoholic extract of Allium eriophyllum in rats with simultaneous type 2 diabetes and renal hypertension. Six groups of male Spargue-Dawley rats (8-10 rats each) including a sham-control, a diabetic group, a renal hypertensive group, three groups of animals with simultaneous diabetes and hypertension receiving vehicle, or the extract at 30 or 100 mg/kg/day were used. Four weeks after receiving vehicle or extract, blood pressure, fasting blood glucose, and serum superoxide dismutase and glutathione reductase levels were measured, and isolated heart studies were performed. Systolic blood pressure, fasting blood glucose, coronary effluent creatine kinase-MB, infarct size and coronary resistance of diabetic hypertensive group receiving vehicle were significantly higher than those of the sham-control group and treatment with the extract prevented the increase of these variables. Moreover, rate of rise and decrease of left ventricular pressure, left ventricular developed pressure, rate pressure product and serum levels of superoxide dismutase and glutathione reductase of diabetic hypertensive group receiving vehicle were significantly lower than those the sham-control group, and treatment with the extract prevented the decrease of these variables. The findings indicate that hydroalcoholic extract of A. eriophyllum leaves, possibly by an antioxidant mechanism, protected against simultaneous diabetes and hypertension-induced cardiac dysfunction.
在动物研究中，已证实葱属家族的某些物种具有心脏保护作用。本研究旨在探讨氧化应激在绵毛葱水醇提取物对2型糖尿病合并肾性高血压大鼠心脏保护作用中的可能作用。使用了六组雄性斯帕格 - 道利大鼠（每组8 - 10只），包括假手术对照组、糖尿病组、肾性高血压组、三组糖尿病合并高血压的动物，分别给予赋形剂，或30或100毫克/千克/天的提取物。在给予赋形剂或提取物四周后，测量血压、空腹血糖、血清超氧化物歧化酶和谷胱甘肽还原酶水平，并进行离体心脏研究。接受赋形剂的糖尿病高血压组的收缩压、空腹血糖、冠状动脉流出液肌酸激酶 - MB、梗死面积和冠状动脉阻力显著高于假手术对照组，而提取物治疗可防止这些变量增加。此外，接受赋形剂的糖尿病高血压组的左心室压力上升和下降速率、左心室舒张末压、速率压力乘积以及超氧化物歧化酶和谷胱甘肽还原酶的血清水平显著低于假手术对照组，提取物治疗可防止这些变量降低。研究结果表明，绵毛葱叶水醇提取物可能通过抗氧化机制，对糖尿病和高血压共同诱导的心脏功能障碍具有保护作用。
