Hajhashemi V, Vaseghi G, Pourfarzam M, Abdollahi A
Department of Pharmacology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R.Iran.
Res Pharm Sci. 2010 Jan;5(1):1-8.
Free radicals are produced continuously in the cells as part of normal cellular function, however excess production might play a role in pathophysiology of many disease conditions, including cancer, Alzheimer's disease, atherosclerosis and some of the drug-induced toxicity. Many basic research studies and observational epidemiologic studies in human suggest that antioxidants can prevent oxidative damage. However, this is still a controversial issue because the results of clinical trials have been inconsistent. This article provides a brief overview of some of the diseases which are associated with free radicals, then discusses the roles of some of dietary antioxidant supplements in disease prevention, with particular reference to the findings of latest clinical trials.
自由基作为正常细胞功能的一部分在细胞中持续产生，然而过量产生可能在许多疾病状态的病理生理学中起作用，包括癌症、阿尔茨海默病、动脉粥样硬化以及一些药物诱导的毒性。许多针对人类的基础研究和观察性流行病学研究表明，抗氧化剂可以预防氧化损伤。然而，这仍然是一个有争议的问题，因为临床试验的结果并不一致。本文简要概述了一些与自由基相关的疾病，然后讨论了一些膳食抗氧化剂补充剂在疾病预防中的作用，特别参考了最新临床试验的结果。
