Mahdinezhad Mohammad Reza, Hooshmand Sara, Soukhtanloo Mohammad, Jamshidi Shirin Taraz, Ehtiati Sajad, Ghorbani Ahmad
Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.
Res Pharm Sci. 2020 Dec 30;16(1):71-78. doi: 10.4103/1735-5362.305190. eCollection 2021 Feb.
Previous studies have shown the antioxidant, anti-inflammatory, immunomodulatory, and hypolipidemic activities of . The aim of the present study was to evaluate the protective effects of hydroalcoholic extract of rhizomes on streptozotocin-induced diabetic rats.
Twenty-four male Wistar rats were randomly assigned into four groups including a normal control group, diabetic control group, diabetic groups treated for 4 weeks with 100 and 200 mg/kg/day of the extract (IGE).
FINDINGS/RESULTS: Induction of diabetes significantly decreased the body weight gain and considerably increased the serum levels of glucose, triglyceride, blood urea nitrogen (BUN), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Diabetes also diminished the antioxidant capacity of the liver (decrease of thiol groups) and significantly degenerated pancreatic islands. The IGE at both doses of 100 and 200 mg/kg significantly reduced the levels of glucose, triglyceride, AST, ALT, and ALP. Moreover, IGE increased the total antioxidant capacity of the liver and ameliorated pancreatic island morphology. The extract had no significant effect on body weight and BUN level.
These findings suggest that rhizomes inhibits the progression of hyperglycemia and hypertriglyceridemia and has protective effects against diabetes-induced injury of the liver and pancreas. Therefore, this plant has the potential to be used as a natural product for controlling diabetes.
先前的研究已表明[具体物质]具有抗氧化、抗炎、免疫调节及降血脂活性。本研究旨在评估[具体植物]根茎水醇提取物对链脲佐菌素诱导的糖尿病大鼠的保护作用。
将24只雄性Wistar大鼠随机分为四组，包括正常对照组、糖尿病对照组、分别用100和200毫克/千克/天的[提取物名称]提取物治疗4周的糖尿病组（IGE）。
糖尿病的诱导显著降低了体重增加，并大幅提高了血清葡萄糖、甘油三酯、血尿素氮（BUN）、天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）和碱性磷酸酶（ALP）水平。糖尿病还降低了肝脏的抗氧化能力（巯基减少），并使胰岛显著退化。100和200毫克/千克剂量的IGE均显著降低了葡萄糖、甘油三酯、AST、ALT和ALP水平。此外，IGE提高了肝脏的总抗氧化能力，并改善了胰岛形态。该提取物对体重和BUN水平无显著影响。
这些发现表明，[具体植物]根茎可抑制高血糖和高甘油三酯血症的进展，并对糖尿病诱导的肝脏和胰腺损伤具有保护作用。因此，这种植物有潜力作为控制糖尿病的天然产物。
