• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

木犀草素通过抑制血管平滑肌细胞的增殖和迁移改善高血压血管重塑。

Luteolin Ameliorates Hypertensive Vascular Remodeling through Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells.

作者信息

Su Jie, Xu Han-Ting, Yu Jing-Jing, Gao Jian-Li, Lei Jing, Yin Qiao-Shan, Li Bo, Pang Min-Xia, Su Min-Xia, Mi Wen-Jia, Chen Su-Hong, Lv Gui-Yuan

机构信息

Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.

Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

出版信息

Evid Based Complement Alternat Med. 2015;2015:364876. doi: 10.1155/2015/364876. Epub 2015 Sep 30.

DOI:10.1155/2015/364876
PMID:26495010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4606148/
Abstract

Objectives. Preliminary researches showed that luteolin was used to treat hypertension. However, it is still unclear whether luteolin has effect on the hypertensive complication such as vascular remodeling. The present study was designed to investigate the effect of luteolin on the hypertensive vascular remodeling and its molecular mechanism. Method and Results. We evaluated the effect of luteolin on aorta thickening of hypertension in spontaneous hypertensive rats (SHRs) and found that luteolin could significantly decrease the blood pressure and media thickness of aorta in vivo. Luteolin could inhibit angiotensin II- (Ang II-) induced proliferation and migration of vascular smooth muscle cells (VSMCs). Dichlorofluorescein diacetate (DCFH-DA) staining result showed that luteolin reduced Ang II-stimulated ROS production in VSMCs. Furthermore, western blot and gelatin zymography results showed that luteolin treatment leaded to a decrease in ERK1/2, p-ERK1/2, p-p38, MMP2, and proliferating cell nuclear antigen (PCNA) protein level. Conclusion. These data support that luteolin can ameliorate hypertensive vascular remodeling by inhibiting the proliferation and migration of Ang II-induced VSMCs. Its mechanism is mediated by the regulation of MAPK signaling pathway and the production of ROS.

摘要

目的。初步研究表明，木犀草素可用于治疗高血压。然而，木犀草素对高血压并发症如血管重塑是否有作用仍不清楚。本研究旨在探讨木犀草素对高血压血管重塑的影响及其分子机制。方法与结果。我们评估了木犀草素对自发性高血压大鼠（SHRs）主动脉增厚的影响，发现木犀草素可显著降低体内血压和主动脉中膜厚度。木犀草素可抑制血管紧张素II（Ang II）诱导的血管平滑肌细胞（VSMCs）增殖和迁移。二氯荧光素二乙酸酯（DCFH-DA）染色结果表明，木犀草素可降低Ang II刺激的VSMCs中活性氧的产生。此外，蛋白质印迹法和明胶酶谱分析结果表明，木犀草素处理导致细胞外信号调节激酶1/2（ERK1/2）、磷酸化ERK1/2（p-ERK1/2）、磷酸化p38（p-p38）、基质金属蛋白酶2（MMP2）和增殖细胞核抗原（PCNA）蛋白水平降低。结论。这些数据支持木犀草素可通过抑制Ang II诱导的VSMCs增殖和迁移来改善高血压血管重塑。其机制是通过调节丝裂原活化蛋白激酶（MAPK）信号通路和活性氧的产生介导的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/af37ea4f0c97/ECAM2015-364876.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/0ad62e5b9514/ECAM2015-364876.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/4fedd2bdee39/ECAM2015-364876.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/70b8cf95a4e1/ECAM2015-364876.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/dc9f023bfe8e/ECAM2015-364876.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/4185fefee610/ECAM2015-364876.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/25a7c303fb56/ECAM2015-364876.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/b69fca369577/ECAM2015-364876.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/af37ea4f0c97/ECAM2015-364876.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/0ad62e5b9514/ECAM2015-364876.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/4fedd2bdee39/ECAM2015-364876.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/70b8cf95a4e1/ECAM2015-364876.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/dc9f023bfe8e/ECAM2015-364876.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/4185fefee610/ECAM2015-364876.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/25a7c303fb56/ECAM2015-364876.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/b69fca369577/ECAM2015-364876.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4b/4606148/af37ea4f0c97/ECAM2015-364876.008.jpg

相似文献

1
Luteolin Ameliorates Hypertensive Vascular Remodeling through Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells.木犀草素通过抑制血管平滑肌细胞的增殖和迁移改善高血压血管重塑。
Evid Based Complement Alternat Med. 2015;2015:364876. doi: 10.1155/2015/364876. Epub 2015 Sep 30.
2
Luteolin Inhibits Angiotensin II-Stimulated VSMC Proliferation and Migration through Downregulation of Akt Phosphorylation.木犀草素通过下调Akt磷酸化抑制血管紧张素II刺激的血管平滑肌细胞增殖和迁移。
Evid Based Complement Alternat Med. 2015;2015:931782. doi: 10.1155/2015/931782. Epub 2015 Aug 10.
3
Qingxuan Jiangya Decoction () Prevents Blood Pressure Elevation and Ameliorates Vascular Structural Remodeling via Modulating TGF-β 1/Smad Pathway in Spontaneously Hypertensive Rats.清眩降压汤通过调控转化生长因子-β1/ Smad 通路防治自发性高血压大鼠血压升高及血管重构
Chin J Integr Med. 2020 Mar;26(3):180-187. doi: 10.1007/s11655-019-2705-7. Epub 2019 Dec 27.
4
Wogonin attenuates vascular remodeling by inhibiting smooth muscle cell proliferation and migration in hypertensive rat.汉黄芩素通过抑制高血压大鼠平滑肌细胞的增殖和迁移来减轻血管重塑。
Korean J Physiol Pharmacol. 2024 Jan 1;28(1):39-48. doi: 10.4196/kjpp.2024.28.1.39.
5
Inhibitory Effects of Hydrogen on Proliferation and Migration of Vascular Smooth Muscle Cells via Down-Regulation of Mitogen/Activated Protein Kinase and Ezrin-Radixin-Moesin Signaling Pathways.氢气通过下调丝裂原/活化蛋白激酶和埃兹蛋白-根蛋白-膜突蛋白信号通路对血管平滑肌细胞增殖和迁移的抑制作用
Chin J Physiol. 2016 Feb 29;59(1):46-55. doi: 10.4077/CJP.2016.BAE365.
6
Luteolin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting TGFBR1 Signaling.木犀草素通过抑制TGFBR1信号传导来抑制血管平滑肌细胞的增殖和迁移。
Front Pharmacol. 2018 Sep 21;9:1059. doi: 10.3389/fphar.2018.01059. eCollection 2018.
7
Regulation of myosin light chain kinase expression by angiotensin II in hypertension.高血压中血管紧张素II对肌球蛋白轻链激酶表达的调节
Am J Hypertens. 2008 Aug;21(8):860-5. doi: 10.1038/ajh.2008.199. Epub 2008 May 29.
8
CX3CL1/CX3CR1 Axis Contributes to Angiotensin II-Induced Vascular Smooth Muscle Cell Proliferation and Inflammatory Cytokine Production.CX3CL1/CX3CR1 轴促进血管平滑肌细胞增殖和炎症细胞因子产生。
Inflammation. 2018 Jun;41(3):824-834. doi: 10.1007/s10753-018-0736-4.
9
MicroRNA-130a mediates proliferation of vascular smooth muscle cells in hypertension.微小 RNA-130a 介导高血压中的血管平滑肌细胞增殖。
Am J Hypertens. 2011 Oct;24(10):1087-93. doi: 10.1038/ajh.2011.116. Epub 2011 Jul 14.
10
Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPARγ-NF-κB signaling pathway in rat vascular smooth muscle cells.金雀异黄素通过内质网 p38/ERK1/2-PPARγ-NF-κB 信号通路抑制血管平滑肌细胞中 Ang II 诱导的 CRP 和 MMP-9 的产生。
Life Sci. 2019 Jan 1;216:140-146. doi: 10.1016/j.lfs.2018.11.036. Epub 2018 Nov 16.

引用本文的文献

1
Effect of 6-methyl-5-hepten-2-one (Sulcatone) on hemostasis parameters in SHR rats: In Silico, In Vitro, and In Vivo approaches.6-甲基-5-庚烯-2-酮（苏合香酮）对自发性高血压大鼠止血参数的影响：计算机模拟、体外和体内研究方法
Naunyn Schmiedebergs Arch Pharmacol. 2025 Sep 1. doi: 10.1007/s00210-025-04556-3.
2
A Comprehensive Review of Cardiovascular Disease Management: Cardiac Biomarkers, Imaging Modalities, Pharmacotherapy, Surgical Interventions, and Herbal Remedies.心血管疾病管理的综合述评：心脏生物标志物、成像方式、药物治疗、手术干预和草药疗法。
Cells. 2024 Sep 1;13(17):1471. doi: 10.3390/cells13171471.
3
Flavonoids: Antioxidant Powerhouses and Their Role in Nanomedicine.

本文引用的文献

1
Combined antihypertensive effect of luteolin and buddleoside enriched extracts in spontaneously hypertensive rats.蒙花苷和芦丁富集提取物对自发性高血压大鼠的联合降压作用。
J Ethnopharmacol. 2013 Nov 25;150(2):507-13. doi: 10.1016/j.jep.2013.08.058. Epub 2013 Sep 28.
2
Tetrandrine Suppresses Cancer Angiogenesis and Metastasis in 4T1 Tumor Bearing Mice.汉防己甲素抑制 4T1 荷瘤小鼠肿瘤血管生成和转移。
Evid Based Complement Alternat Med. 2013;2013:265061. doi: 10.1155/2013/265061. Epub 2013 May 25.
3
Diallylsulfide attenuates excessive collagen production and apoptosis in a rat model of bleomycin induced pulmonary fibrosis through the involvement of protease activated receptor-2.
黄酮类化合物：抗氧化强者及其在纳米医学中的作用
Antioxidants (Basel). 2024 Jul 29;13(8):922. doi: 10.3390/antiox13080922.
4
Marine sourced tripeptide SRP and its sustained-release formulation SRP-PLGA-MS exhibiting antihypertensive effect in spontaneously hypertensive rats and HUVECs.海洋来源的三肽SRP及其缓释制剂SRP-PLGA-MS在自发性高血压大鼠和人脐静脉内皮细胞中表现出降压作用。
Front Nutr. 2024 Jun 12;11:1423098. doi: 10.3389/fnut.2024.1423098. eCollection 2024.
5
Antihypertensive Property of Celery: A Narrative Review on Current Knowledge.芹菜的降压特性：当前知识的叙述性综述
Int J Food Sci. 2024 Mar 12;2024:9792556. doi: 10.1155/2024/9792556. eCollection 2024.
6
Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review.植物多酚及其对心血管健康的潜在益处：综述。
Molecules. 2023 Sep 1;28(17):6403. doi: 10.3390/molecules28176403.
7
Bioflavonoid luteolin prevents sFlt-1 release via HIF-1α inhibition in cultured human placenta.生物类黄酮木樨草素通过抑制缺氧诱导因子-1α（HIF-1α）抑制人胎盘绒毛滋养层细胞 sFlt-1 的释放。
FASEB J. 2023 Aug;37(8):e23078. doi: 10.1096/fj.202300611R.
8
Geraniin Ameliorates Hypertensive Vascular Remodelling in a Diet-Induced Obese Animal Model through Antioxidant and Anti-Inflammatory Effects.橙皮苷通过抗氧化和抗炎作用改善饮食诱导肥胖动物模型的高血压血管重塑。
Nutrients. 2023 Jun 9;15(12):2696. doi: 10.3390/nu15122696.
9
Table olive elicits antihypertensive activity in spontaneously hypertensive rats.鲜食橄榄对自发性高血压大鼠具有降压活性。
J Sci Food Agric. 2023 Jan 15;103(1):64-72. doi: 10.1002/jsfa.12112. Epub 2022 Jul 26.
10
Safety evaluation and biochemical efficacy of celery seed extract (Apium Graveolens) capsules in hypertensive patients: a randomized, triple-blind, placebo-controlled, cross-over, clinical trial.芹菜籽提取物（Apium Graveolens）胶囊治疗高血压患者的安全性评价及生化功效：一项随机、三盲、安慰剂对照、交叉临床试验。
Inflammopharmacology. 2022 Oct;30(5):1669-1684. doi: 10.1007/s10787-022-00986-0. Epub 2022 May 10.
二烯丙基二硫通过激活蛋白酶激活受体-2减轻博来霉素诱导的肺纤维化大鼠模型中胶原过度产生和细胞凋亡。
Toxicol Appl Pharmacol. 2013 Sep 1;271(2):184-95. doi: 10.1016/j.taap.2013.04.021. Epub 2013 May 5.
4
The flavonoid luteolin induces nitric oxide production and arterial relaxation.类黄酮木犀草素诱导一氧化氮产生和动脉舒张。
Eur J Nutr. 2014 Feb;53(1):269-75. doi: 10.1007/s00394-013-0525-7. Epub 2013 Apr 21.
5
Chrysin and luteolin attenuate diabetes-induced impairment in endothelial-dependent relaxation: effect on lipid profile, AGEs and NO generation.白杨黄素和木樨草素可减轻糖尿病引起的内皮依赖性松弛损伤：对脂谱、AGEs 和 NO 生成的影响。
Phytother Res. 2013 Nov;27(11):1678-84. doi: 10.1002/ptr.4917. Epub 2013 Jan 7.
6
Luteolin inhibits pyrogallol-induced apoptosis through the extracellular signal-regulated kinase signaling pathway.木犀草素通过细胞外信号调节激酶信号通路抑制焦性没食子酸诱导的细胞凋亡。
FEBS J. 2012 May;279(10):1834-43. doi: 10.1111/j.1742-4658.2012.08558.x. Epub 2012 Apr 4.
7
iPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling.iPLA2β 在平滑肌中的过度表达加剧了血管紧张素Ⅱ诱导的高血压和血管重构。
PLoS One. 2012;7(2):e31850. doi: 10.1371/journal.pone.0031850. Epub 2012 Feb 20.
8
Mitogen-activated protein kinase-activated protein kinase 2 in angiotensin II-induced inflammation and hypertension: regulation of oxidative stress.丝裂原活化蛋白激酶激活的蛋白激酶 2 在血管紧张素Ⅱ诱导的炎症和高血压中的作用：氧化应激的调节。
Hypertension. 2011 Feb;57(2):245-54. doi: 10.1161/HYPERTENSIONAHA.110.159889. Epub 2010 Dec 20.
9
Luteolin prevents LPS-induced TNF-α expression in cardiac myocytes through inhibiting NF-κB signaling pathway.木犀草素通过抑制 NF-κB 信号通路防止 LPS 诱导的心肌细胞 TNF-α 表达。
Inflammation. 2011 Dec;34(6):620-9. doi: 10.1007/s10753-010-9271-7.
10
Olmesartan inhibits angiotensin II-Induced migration of vascular smooth muscle cells through Src and mitogen-activated protein kinase pathways.奥美沙坦通过Src 和丝裂原活化蛋白激酶通路抑制血管平滑肌细胞的血管紧张素 II 诱导的迁移。
J Pharmacol Sci. 2010;113(2):161-8. doi: 10.1254/jphs.09332fp. Epub 2010 May 28.