Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee (SRC), Mashhad University of Medical Sciences, Mashhad, Iran.
Inflammopharmacology. 2022 Oct;30(5):1669-1684. doi: 10.1007/s10787-022-00986-0. Epub 2022 May 10.
The present study was conducted to evaluate the safety of celery seed extract (Apium graveolens), as a medicinal herb with active ingredients such as 3-n-butylphthalide (NBP), in hypertensive patients. This study was a randomized, triple-blind, placebo-controlled, cross-over clinical trial. Hypertensive patients (51 participants) received 4 celery seed capsules (a total of 1.34 g extract per day) or 4 placebo capsules per day for 4 weeks as a supplement to their usual medication regimen. The results indicated that the celery seed capsule not only was safe for hypertensive patients but also caused a reduction in BP, FBS, and lipid profile values. Also, it had beneficial effects on kidney and liver functions. No significant change was observed in blood cells and serum electrolytes (p > 0.05). The mean reduction in BUN and SCr were 3.43 and 0.075 mg/dL, and in SGPT and SGOT were 4.08 and 3.03 U/L, respectively (p < 0.05). FBS reduced from 108.53 to 97.96 mg/dL after 4 weeks of celery administration (p < 0.01). The decrease in TC, TG, LDL, and increase in HDL were 16.37, 16.22, 11.84, and 2.52 mg/dL, respectively (p < 0.001). According to the promising results of this clinical trial, celery seed extract can be considered a safe supplement for hypertensive patients. The study is limited by the small sample size; therefore, larger randomized trials are required.
本研究旨在评估芹菜籽提取物（Apium graveolens）作为一种药用植物的安全性，其有效成分包括 3-正丁基苯酞（NBP），适用于高血压患者。这是一项随机、三盲、安慰剂对照、交叉临床试验。高血压患者（51 名参与者）每天服用 4 粒芹菜籽胶囊（每天共摄入 1.34g 提取物）或 4 粒安慰剂胶囊，作为其常规药物治疗方案的补充。结果表明，芹菜籽胶囊不仅对高血压患者安全，而且可降低血压、空腹血糖和血脂谱值。此外，它对肾功能和肝功能也有有益影响。血细胞和血清电解质没有明显变化（p＞0.05）。BUN 和 SCr 的平均降低值分别为 3.43mg/dL 和 0.075mg/dL，SGPT 和 SGOT 分别降低 4.08U/L 和 3.03U/L（p＜0.05）。芹菜服用 4 周后，空腹血糖从 108.53mg/dL 降至 97.96mg/dL（p＜0.01）。TC、TG、LDL 降低值和 HDL 升高值分别为 16.37mg/dL、16.22mg/dL、11.84mg/dL 和 2.52mg/dL（p＜0.001）。根据这项临床试验的有希望的结果，芹菜籽提取物可以被认为是高血压患者安全的补充剂。该研究受到样本量小的限制，因此需要更大规模的随机试验。
