Abu-Remaileh Muhannad, Joy-Dodson Emma, Schueler-Furman Ora, Aqeilan Rami I
From the Departments of Immunology & Cancer Research and.
Microbiology & Molecular Genetics, Institute for Medical Research Israel-Canada (IMRIC), Hebrew University-Hadassah Medical School, Jerusalem, Israel 91120.
J Biol Chem. 2015 Dec 25;290(52):30728-35. doi: 10.1074/jbc.R115.676346. Epub 2015 Oct 23.
WW domain-containing oxidoreductase (WWOX), originally marked as a likely tumor suppressor gene, has over the years become recognized for its role in a much wider range of cellular activities. Phenotypic effects displayed in animal studies, along with resolution of WWOX's architecture, fold, and binding partners, point to the protein's multifaceted biological functions. Results from a series of complementary experiments seem to indicate WWOX's involvement in metabolic regulation. More recently, clinical studies involving cases of severe encephalopathy suggest that WWOX also plays a part in controlling CNS development, further expanding our understanding of the breadth and complexity of WWOX behavior. Here we present a short overview of the various approaches taken to study this dynamic gene, emphasizing the most recent findings regarding WWOX's metabolic- and CNS-associated functions and their underlying molecular basis.
含WW结构域氧化还原酶（WWOX）最初被视为一种潜在的肿瘤抑制基因，多年来，人们逐渐认识到它在更广泛的细胞活动中发挥作用。动物研究中显示的表型效应，以及对WWOX结构、折叠和结合伙伴的解析，都指向了该蛋白多方面的生物学功能。一系列互补实验的结果似乎表明WWOX参与代谢调节。最近，涉及严重脑病病例的临床研究表明，WWOX在控制中枢神经系统发育中也发挥作用，这进一步拓展了我们对WWOX行为广度和复杂性的理解。在此，我们简要概述研究这个动态基因所采用的各种方法，重点介绍关于WWOX与代谢及中枢神经系统相关功能及其潜在分子基础的最新发现。
