Dai Yan-Cheng, Zhang Ya-Li, Wang Li-Juan, Guo Qian, Yang Kun, Ye Ren-Hao, Tang Zhi-Peng
Department of Gastroenterology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Institute of Digestive Disease Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Chin J Integr Med. 2016 Nov;22(11):811-816. doi: 10.1007/s11655-015-2118-1. Epub 2015 Oct 26.
Complementary and alternative medicine, particularly herbal therapy, is widely used by patients with ulcerative colitis (UC), but controlled data are limited. To describe the clinical presentation and treatment strategies for UC in inpatients from Shanghai, China and to improve the therapeutic outcomes for patients with UC.
Medical records from 247 patients with UC who were admitted to Longhua Hospital Affifiliated to Shanghai University of Traditional Chinese Medicine between January 2008 and June 2013 were analyzed for gender, age, course of the disease, clinical type, extent and severity of the disease, treatment strategies, and therapeutic outcomes.
Gender ratios and disease onset of inpatients with UC in the Shanghai area were consistent with other reports in the literature. In contrast to previous studies, most patients exhibited disease of the left colon, over half of the patients had problems of the rectum or sigmoid colon, and most patients had either mild or moderate UC. Comparison of Sutherland Disease Actirity Index scores for patients treated with Chinese medicine (CM) and those treated with integrated CM and Western medicine revealed signifificant reductions in scores for both groups after treatment (P<0.01), with no signifificant difference in therapeutic effects between groups (P=0.938).
Herbal medicine has been widely used in patients with mild to moderate disease and as adjunct therapy in patients with moderate to severe disease. Therefore, the strategy was proposed for the treatment of UC with CM therapy based on 2 steps according to the stage of the disease, even in the clinical setting.
补充和替代医学，尤其是草药疗法，被溃疡性结肠炎（UC）患者广泛使用，但对照数据有限。描述中国上海住院的UC患者的临床表现和治疗策略，以改善UC患者的治疗效果。
分析2008年1月至2013年6月期间入住上海中医药大学附属龙华医院的247例UC患者的病历，内容包括性别、年龄、病程、临床类型、疾病范围和严重程度、治疗策略及治疗效果。
上海地区UC住院患者的性别比例和发病情况与文献中的其他报道一致。与先前研究不同的是，大多数患者表现为左半结肠疾病，超过半数患者存在直肠或乙状结肠问题，且大多数患者为轻度或中度UC。对接受中药治疗（CM）和中西医结合治疗的患者的utherland疾病活动指数评分进行比较，结果显示两组治疗后评分均显著降低（P<0.01），两组治疗效果无显著差异（P=0.938）。
草药已广泛用于轻度至中度疾病患者，并作为中度至重度疾病患者的辅助治疗。因此，即使在临床环境中，也建议根据疾病阶段分两步采用中药疗法治疗UC。
