Bauer Julia, Osborn Helen M I
Reading School of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
Future Med Chem. 2015;7(16):2285-99. doi: 10.4155/fmc.15.135. Epub 2015 Oct 29.
It is now well documented that carbohydrates play multiple roles in biological processes, and hence are interesting targets for chemical biology and medicinal chemistry programs. This review focuses on a subset of carbohydrates, specifically sialic acid containing carbohydrates. It highlights their occurrence and diversity, and presents evidence for their roles in a range of biological pathways. It illustrates that they are targets for novel medicinal chemistry strategies for a range of therapeutic areas, including cancer and immunity. Case studies highlight opportunities and challenges in this area, and sialic acid-based drugs that have entered clinical practice and are promising candidates for future disease intervention schemes, are discussed. The review concludes by highlighting perspectives and emerging roles for these targets.
现在有充分的文献记载，碳水化合物在生物过程中发挥着多种作用，因此是化学生物学和药物化学研究项目感兴趣的目标。本综述聚焦于碳水化合物的一个子集，特别是含唾液酸的碳水化合物。它强调了它们的存在和多样性，并提供了它们在一系列生物途径中发挥作用的证据。它表明，它们是包括癌症和免疫在内的一系列治疗领域新型药物化学策略的目标。案例研究突出了该领域的机遇和挑战，并讨论了已进入临床实践且有望用于未来疾病干预方案的基于唾液酸的药物。综述最后强调了这些目标的前景和新出现的作用。
