Di Stolfo Giuseppe, Mastroianno Sandra, Potenza Domenico Rosario, De Luca Giovanni, d'Arienzo Carmela, Pacilli Michele Antonio, Fanelli Mario, Russo Aldo, Fanelli Raffaele
Cardiovascular Department, Ospedale Casa Sollievo della Sofferenza, viale Cappuccini, San Giovanni Rotondo, Italy.
Cardiologia Universitaria, University of Foggia, Ospedali Riuniti Di Foggia, viale Luigi Pinto, Foggia, Italy.
J Geriatr Cardiol. 2015 Sep;12(5):515-20. doi: 10.11909/j.issn.1671-5411.2015.05.008.
Many epidemiological studies analyze the relationship between hyperuricemia and cardiovascular outcomes. This observational prospective study investigates the association of serum uric acid (SUA) levels with adverse cardiovascular events and deaths in an elderly population affected by advanced atherosclerosis.
Two hundred and seventy six elderly patients affected by advanced atherosclerosis (217 males and 59 females; aged 71.2 ± 7.8 years) were included. All patients were assessed for history of cardiovascular disease, cancer, obesity and traditional risk factors. Patients were followed for approximately 31 ± 11 months. Major events were recorded during follow-up, defined as myocardial infarction, cerebral ischemia, myocardial and/or peripheral revascularization and death.
Mean SUA level was 5.47 ± 1.43 mg/dL; then we further divided the population in two groups, according to the median value (5.36 mg/dL). During a median follow up of 31 months (5 to 49 months), 66 cardiovascular events, 9 fatal cardiovascular events and 14 cancer-related deaths have occurred. The patients with increased SUA level presented a higher significant incidence of total cardiovascular events (HR: 1.867, P = 0.014, 95% CI: 1.134-3.074). The same patients showed a significant increased risk of cancer-related death (HR: 4.335, P = 0.025, 95% CI: 1.204-15.606).
Increased SUA levels are independently and significantly associated with risk of cardiovascular events and cancer related death in a population of mainly elderly patients affected by peripheral vasculopathy.
许多流行病学研究分析了高尿酸血症与心血管疾病转归之间的关系。这项观察性前瞻性研究调查了血清尿酸（SUA）水平与患有晚期动脉粥样硬化的老年人群不良心血管事件及死亡之间的关联。
纳入了276例患有晚期动脉粥样硬化的老年患者（217例男性和59例女性；年龄71.2±7.8岁）。所有患者均评估了心血管疾病、癌症、肥胖及传统危险因素的病史。对患者进行了约31±11个月的随访。随访期间记录主要事件，定义为心肌梗死、脑缺血、心肌和/或外周血管重建及死亡。
平均SUA水平为5.47±1.43mg/dL；然后我们根据中位数（5.36mg/dL）将人群进一步分为两组。在31个月（5至49个月）的中位随访期间，发生了66例心血管事件、9例致命心血管事件和14例癌症相关死亡。SUA水平升高的患者总心血管事件的发生率显著更高（HR：1.867，P=0.014，95%CI：1.134-3.074）。同样这些患者癌症相关死亡风险显著增加（HR：4.335，P=0.025，95%CI：1.204-15.606）。
在主要为患有外周血管病变的老年人群中，SUA水平升高与心血管事件风险及癌症相关死亡独立且显著相关。
