CYP1A2基因rs762551多态性与膀胱癌易感性的关联：基于病例对照研究的Meta分析

Association between the CYP1A2 rs762551 Polymorphism and Bladder Cancer Susceptibility: a Meta-Analysis Based on Case-Control Studies.

作者信息

Zeng Yong, Jiang Hua-Yong, Wei Li, Xu Wei-Dong, Wang Ya-Jie, Wang Ya-Di, Liu Chuan

机构信息

Department of Cardiothoracic Surgery, Shaoxing People's Hospital , Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang Province, China E-mail :

出版信息

Asian Pac J Cancer Prev. 2015;16(16):7249-54. doi: 10.7314/apjcp.2015.16.16.7249.

DOI:10.7314/apjcp.2015.16.16.7249

PMID:26514519

Abstract

BACKGROUND

Previous studies evaluated associations between the CYP1A2 rs762551 polymorphism and bladder cancer risk. However, the results were inconsistent. We therefore performed a meta-analysis of the published case-control studies to assess in detail the association between CYP1A2 rs762551 polymorphism and bladder cancer risk.

MATERIALS AND METHODS

PubMed, Embase and Web of Science were searched to identify relevant studies and the pooled odds ratio (OR) and 95 % confidence interval (95%CI) were calculated.

RESULTS

A total of seven articles including 3,013 cases and 2,771 controls were finally included. Overall, a significant association was found between the CYP1A2 rs762551 polymorphism and bladder cancer susceptibility for CC vs AA (OR=0.82, 95% CI=0.69~~0.99), but no significant associations were found for the other three models (AC vs AA: OR=0.91, 95% CI=0.81~~1.02; the dominant model: OR=0.90, 95% CI=0.80~~1.00; the recessive model: OR=0.84, 95% CI =0.72~~1.00). In the subgroup analysis by ethnicity, we detected significant associations between the CYP1A2 rs762551 polymorphism and bladder cancer susceptibility for GA vs GG (OR = 0.78, 95% CI =0.64~~0.96) and for the recessive model (OR=0.80, 95% CI=0.66~~0.96) in Caucasians, but not for Asians.

CONCLUSIONS

The results from the meta-analysis suggested that the CYP1A2 rs762551 polymorphism is a protective factor for bladder cancer, especially in Caucasians.

摘要

背景

既往研究评估了CYP1A2基因rs762551多态性与膀胱癌风险之间的关联。然而，结果并不一致。因此，我们对已发表的病例对照研究进行了荟萃分析，以详细评估CYP1A2基因rs762551多态性与膀胱癌风险之间的关联。

材料与方法

检索了PubMed、Embase和Web of Science以识别相关研究，并计算合并比值比（OR）和95%置信区间（95%CI）。

结果

最终纳入了7篇文章，包括3013例病例和2771例对照。总体而言，发现CYP1A2基因rs762551多态性与膀胱癌易感性在CC与AA比较时存在显著关联（OR=0.82，95%CI=0.69~~0.99），但在其他三种模型中未发现显著关联（AC与AA比较：OR=0.91，95%CI=0.81~~1.02；显性模型：OR=0.90，95%CI=0.80~~1.00；隐性模型：OR=0.84，95%CI=0.72~~1.00）。在按种族进行的亚组分析中，我们在白种人中检测到CYP1A2基因rs762551多态性与膀胱癌易感性在GA与GG比较时（OR=0.78，95%CI=0.64~~0.96）以及隐性模型（OR=0.80，95%CI=0.66~~0.96）存在显著关联，但在亚洲人中未发现。