Department of Biochemistry, College of Science, Mansoura University, Mansoura, Egypt.
Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Mol Biol Rep. 2024 Jul 15;51(1):815. doi: 10.1007/s11033-024-09791-0.
Urinary bladder cancer (UBC)is a common tumor of the urinary tract.
To assess the diagnostic significance of IL6 rs1800796 gene polymorphism and IL6 serum level among Egyptian patients with UBC.
One hundred patients with UBC were selected from the Mansoura Urology and Nephrology Center, in addition to 100 healthy control subjects; using PCR and ELISA techniques for IL6 detection.
The rs1800796 GC, CC genotypes, and C allele were significantly more prevalent in the cases with bladder cancer compared to the healthy group (p < 0.001, = 0.021, < 0.001 respectively). There was a clear association between elevated levels of IL6 and bladder cancer versus the control group (median = 4.2, 0.89 respectively, p < 0.001). Serum IL6 levels showed significantly higher levels in patients carrying CC, followed by GC then GG genotypes. No significant association was found between IL6 rs1800796 gene polymorphism or serum level with demographic or laboratory data.
It is suggested that there is a clear link between elevated IL6 levels as well as IL6 rs1800796 gene polymorphism with bladder cancer, suggesting their potential utility as biomarkers for the disease.
膀胱癌（UBC）是一种常见的泌尿道肿瘤。
评估 IL6 rs1800796 基因多态性和 IL6 血清水平在埃及 UBC 患者中的诊断意义。
从曼苏拉泌尿肾病中心选择了 100 例 UBC 患者，以及 100 例健康对照者；采用 PCR 和 ELISA 技术检测 IL6。
与健康组相比，膀胱癌患者中 rs1800796 GC、CC 基因型和 C 等位基因明显更为常见（p<0.001、=0.021、<0.001 分别）。与对照组相比，IL6 水平升高与膀胱癌之间存在明确关联（中位数分别为 4.2、0.89，p<0.001）。CC 基因型患者的血清 IL6 水平明显更高，其次是 GC 基因型，然后是 GG 基因型。IL6 rs1800796 基因多态性或血清水平与人口统计学或实验室数据之间无显著相关性。
IL6 水平升高以及 IL6 rs1800796 基因多态性与膀胱癌之间存在明确联系，提示它们可能作为疾病的生物标志物。
