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对一株来自巴西的无毒力、侵袭性白喉棒状杆菌菌株的基因组分析。

Genomic analysis of a nontoxigenic, invasive Corynebacterium diphtheriae strain from Brazil.

作者信息

Encinas Fernando, Marin Michel A, Ramos Juliana N, Vieira Verônica V, Mattos-Guaraldi Ana Luiza, Vicente Ana Carolina P

机构信息

Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.

Laboratório de Difteria e Corinebactérias de Importância Clínica, Faculdade de Medicina, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

出版信息

Mem Inst Oswaldo Cruz. 2015 Sep;110(6):817-9. doi: 10.1590/0074-02760150250.

DOI:10.1590/0074-02760150250
PMID:26517665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4667589/
Abstract

We report the complete genome sequence and analysis of an invasive Corynebacterium diphtheriae strain that caused endocarditis in Rio de Janeiro, Brazil. It was selected for sequencing on the basis of the current relevance of nontoxigenic strains for public health. The genomic information was explored in the context of diversity, plasticity and genetic relatedness with other contemporary strains.

摘要

我们报告了一株侵袭性白喉棒状杆菌的全基因组序列及分析结果，该菌株在巴西里约热内卢引发了心内膜炎。基于非产毒株对公共卫生的当前相关性，它被选作测序对象。在与其他当代菌株的多样性、可塑性及遗传相关性的背景下，对该基因组信息进行了探究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9602/4667589/0405fc1baa6b/0074-0276-mioc-110-6-0817-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9602/4667589/f4cfa82fdab6/0074-0276-mioc-110-6-0817-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9602/4667589/0405fc1baa6b/0074-0276-mioc-110-6-0817-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9602/4667589/f4cfa82fdab6/0074-0276-mioc-110-6-0817-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9602/4667589/0405fc1baa6b/0074-0276-mioc-110-6-0817-gf02.jpg

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Microbiology (Reading). 2014 Mar;160(Pt 3):537-546. doi: 10.1099/mic.0.069948-0. Epub 2013 Dec 16.
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A lack of genetic basis for biovar differentiation in clinically important Corynebacterium diphtheriae from whole genome sequencing.通过全基因组测序发现，临床重要的白喉棒状杆菌生物变种分化缺乏遗传基础。
Infect Genet Evol. 2014 Jan;21:54-7. doi: 10.1016/j.meegid.2013.10.019. Epub 2013 Nov 5.
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PhiSpy: a novel algorithm for finding prophages in bacterial genomes that combines similarity- and composition-based strategies.
PhiSpy：一种新型算法，用于在细菌基因组中寻找噬菌体，该算法结合了基于相似性和组成的策略。
Nucleic Acids Res. 2012 Sep;40(16):e126. doi: 10.1093/nar/gks406. Epub 2012 May 14.
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An increase in non-toxigenic Corynebacterium diphtheriae infections in Poland--molecular epidemiology and antimicrobial susceptibility of strains isolated from past outbreaks and those currently circulating in Poland.波兰非产毒株白喉棒状杆菌感染的增加——从过去暴发疫情和目前在波兰流行的菌株中分离出的菌株的分子流行病学和抗菌药物敏感性。
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progressiveMauve: multiple genome alignment with gene gain, loss and rearrangement.渐进紫：具有基因增益、缺失和重排的多基因组比对。
PLoS One. 2010 Jun 25;5(6):e11147. doi: 10.1371/journal.pone.0011147.
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