Blumberg Dana, Skaat Alon, Liebmann Jeffrey M
Bernard and Shirlee Brown Glaucoma Research Laboratory, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, NY, USA.
Goldschleger Eye Institute, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Prog Brain Res. 2015;221:81-101. doi: 10.1016/bs.pbr.2015.04.007. Epub 2015 Jul 2.
Glaucoma is a complex, multifactorial neurodegenerative disease process that leads to progressive damage to the optic nerve and irreversible visual impairment. Identification of ocular and systemic risk factors for disease onset and progression is critical for disease detection and surveillance. Although a great deal is known about risk factors for glaucoma, our expanding knowledge of glaucoma genotypes and phenotypes combined with advancements in technology and understanding of disease progression is rapidly enhancing our understanding of who is at greatest risk for glaucomatous visual impairment.
青光眼是一种复杂的、多因素的神经退行性疾病过程，会导致视神经的渐进性损伤和不可逆的视力损害。识别疾病发生和进展的眼部及全身危险因素对于疾病的检测和监测至关重要。尽管我们对青光眼的危险因素已经了解很多，但随着我们对青光眼基因型和表型的认识不断扩展，以及技术进步和对疾病进展的理解，我们对谁最易患青光眼性视力损害的认识正在迅速提高。
