Chen Ruoqing, Regodón Wallin Amanda, Sjölander Arvid, Valdimarsdóttir Unnur, Ye Weimin, Tiemeier Henning, Fall Katja, Almqvist Catarina, Czene Kamila, Fang Fang
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
Elife. 2015 Oct 31;4:e08500. doi: 10.7554/eLife.08500.
A parental cancer diagnosis is psychologically straining for the whole family. We investigated whether a parental cancer diagnosis is associated with a higher-than-expected risk of injury among children by using a Swedish nationwide register-based cohort study. Compared to children without parental cancer, children with parental cancer had a higher rate of hospital contact for injury during the first year after parental cancer diagnosis (hazard ratio [HR] = 1.27, 95% confidence interval [CI] = 1.22-1.33), especially when the parent had a comorbid psychiatric disorder after cancer diagnosis (HR = 1.41, 95% CI = 1.08-1.85). The rate increment declined during the second and third year after parental cancer diagnosis (HR = 1.10, 95% CI = 1.07-1.14) and became null afterwards (HR = 1.01, 95% CI = 0.99-1.03). Children with parental cancer also had a higher rate of repeated injuries than the other children (HR = 1.13, 95% CI = 1.12-1.15). Given the high rate of injury among children in the general population, our findings may have important public health implications.
父母一方被诊断患有癌症会给整个家庭带来心理压力。我们通过一项基于瑞典全国登记的队列研究，调查了父母一方被诊断患有癌症是否与儿童受伤风险高于预期有关。与父母未患癌症的儿童相比，父母患癌症的儿童在父母癌症诊断后的第一年因受伤而就医的比例更高（风险比[HR]=1.27，95%置信区间[CI]=1.22-1.33），尤其是当父母在癌症诊断后患有共病精神障碍时（HR=1.41，95%CI=1.08-1.85）。在父母癌症诊断后的第二年和第三年，发生率的增幅下降（HR=1.10，95%CI=1.07-1.14），之后变为零（HR=1.01，95%CI=0.99-1.03）。父母患癌症的儿童反复受伤的比例也高于其他儿童（HR=1.13，95%CI=1.12-1.15）。鉴于普通人群中儿童受伤率较高，我们的研究结果可能具有重要的公共卫生意义。
