Xu Xin-Da, Ding Chen-Ru, Yu Jing, Han Zhao, Gu Jun, Gao Na, Jia Xian-Hao, Luo Xu, Wang Jing, Chi Fang-Lu
Department of Otology and Skull Base Surgery, Eye Ear Nose & Throat Hospital, Fudan University, 83 Fenyang Road, Shanghai 200031, China; Shanghai Auditory Medical Center, Shanghai, China; Key Laboratory of Hearing Science, Ministry of Health, Shanghai, China.
Department of Otology and Skull Base Surgery, Eye Ear Nose & Throat Hospital, Fudan University, 83 Fenyang Road, Shanghai 200031, China; Shanghai Auditory Medical Center, Shanghai, China; Key Laboratory of Hearing Science, Ministry of Health, Shanghai, China.
Hear Res. 2016 Jan;331:41-6. doi: 10.1016/j.heares.2015.10.006. Epub 2015 Oct 28.
To define the profiles of ocular and cervical vestibular-evoked myogenic potentials (oVEMP and cVEMP, respectively) in patients with profound sensorineural hearing loss (PSHL).
Twenty-nine patients with PSHL and 20 healthy volunteers were investigated. The patients' medical records were collected and analyzed. The ACS-evoked oVEMPs and cVEMPs and caloric test were tested and analyzed.
The oVEMP and cVEMP response rates in the patients with PSHL were 38.9% and 44.4%, respectively, and these values were significantly less than those in the healthy volunteers (both were 100%). Regarding the oVEMPs, significantly higher threshold (p < 0.001) and smaller amplitude (p = 0.022) were observed in the patients. Regarding the cVEMPs, a significant elevation in the threshold (p < 0.001) and a decrease in the amplitude (p = 0.024) were observed, and marked reductions in the P1 (p = 0.002) and N1 latencies (p = 0.001) were observed in the patients. Regarding the caloric test, the ratio of semicircular canal dysfunction in patients with PSHL was significantly higher than that in healthy volunteers (p < 0.001). However, neither the patients nor the doctors noticed balance problems or the loss of otolithic function in the summaries of the medical records of all 29 of the patients.
The utricular and saccular dysfunction that can be concealed in patients with PSHL can be observed in oVEMPs and cVEMPs. Otolithic function should receive attention in the diagnosis and treatment of PSHL. VEMPs have special value for the observation of hidden dysfunctions of the otolithic organs of patients with PSHL.
明确重度感音神经性听力损失（PSHL）患者的眼震前庭诱发肌源性电位（分别为oVEMP和cVEMP）特征。
对29例PSHL患者和20名健康志愿者进行研究。收集并分析患者的病历。测试并分析ACS诱发的oVEMP和cVEMP以及冷热试验。
PSHL患者的oVEMP和cVEMP反应率分别为38.9%和44.4%，这些值显著低于健康志愿者（均为100%）。关于oVEMP，患者中观察到阈值显著更高（p < 0.001）且振幅更小（p = 0.022）。关于cVEMP，观察到阈值显著升高（p < 0.001）且振幅降低（p = 0.024），并且患者中P1潜伏期（p = 0.002）和N1潜伏期显著缩短（p = 0.001）。关于冷热试验，PSHL患者的半规管功能障碍比率显著高于健康志愿者（p < 0.001）。然而，在所有29例患者的病历总结中，患者和医生均未注意到平衡问题或耳石功能丧失。
在oVEMP和cVEMP中可观察到PSHL患者中可能隐匿的椭圆囊和球囊功能障碍。在PSHL的诊断和治疗中应关注耳石功能。VEMP对观察PSHL患者耳石器官的隐匿性功能障碍具有特殊价值。
