禁食期间的转录和染色质调控——基因组时代
Transcriptional and Chromatin Regulation during Fasting - The Genomic Era.
作者信息
Goldstein Ido, Hager Gordon L
机构信息
Laboratory of Receptor Biology and Gene Expression, The National Cancer Institute, The National institutes of Health, Bethesda, MD, 20892, USA.
出版信息
Trends Endocrinol Metab. 2015 Dec;26(12):699-710. doi: 10.1016/j.tem.2015.09.005. Epub 2015 Oct 29.
Abstract
An elaborate metabolic response to fasting is orchestrated by the liver and is heavily reliant on transcriptional regulation. In response to hormones (glucagon, glucocorticoids) many transcription factors (TFs) are activated and regulate various genes involved in metabolic pathways aimed at restoring homeostasis: gluconeogenesis, fatty acid oxidation, ketogenesis, and amino acid shuttling. We summarize recent discoveries regarding fasting-related TFs with an emphasis on genome-wide binding patterns. Collectively, the findings we discuss reveal a large degree of cooperation between TFs during fasting that occurs at motif-rich DNA sites bound by a combination of TFs. These new findings implicate transcriptional and chromatin regulation as major determinants of the response to fasting and unravels the complex, multi-TF nature of this response.
摘要
肝脏精心编排了对禁食的复杂代谢反应，且该反应严重依赖转录调控。作为对激素（胰高血糖素、糖皮质激素）的响应，许多转录因子（TFs）被激活，并调节参与旨在恢复体内平衡的代谢途径的各种基因：糖异生、脂肪酸氧化、生酮作用和氨基酸穿梭。我们总结了关于禁食相关转录因子的最新发现，重点是全基因组结合模式。总体而言，我们讨论的这些发现揭示了禁食期间转录因子之间在富含基序的DNA位点上发生的大量合作，这些位点由多种转录因子结合。这些新发现表明转录和染色质调控是对禁食反应的主要决定因素，并揭示了这种反应复杂的多转录因子性质。
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