García-Hermoso A, Notario-Pacheco B, Recio-Rodríguez J I, Martínez-Vizcaíno V, Rodrigo de Pablo E, Magdalena Belio J F, Gómez-Marcos M A, García-Ortiz L
Laboratorio de Ciencias de la Actividad Física, el Deporte y la Salud, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, USACH, Chile.
Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain.
Atherosclerosis. 2015 Dec;243(2):516-22. doi: 10.1016/j.atherosclerosis.2015.10.004.
Arterial stiffness is a contributor to the development of atherosclerosis and cardiovascular disease. The aim of the study was to analyse the relationship between sedentary behaviour and arterial stiffness in a Spanish adult population.
This cross-sectional study included 1365 subjects belonging to the EVIDENT project. Physical activity and sedentary behaviour were measured objectively over 7 days using ActiGraph accelerometers. Thresholds of 10 consecutive minutes were used to estimate the daily sedentary time in bouts ≥10 min. Each interruption in sedentary time (counts/min ≥100) was considered a break. Arterial stiffness was evaluated using the B-pro device through the following indicators: radial Augmentation Index (rAIx), Ambulatory Arterial Stiffness Index (AASI), and central and peripheral pulse pressure (PP).
We found a positive relationship between central and peripheral pulse pressure (office, 24 h, awake and sleep PP) and total sedentary time. These arterial stiffness parameters were also associated with sedentary time in bouts ≥10 min. Significance disappeared in both cases, however, after adjusting for MVPA and breaks per sedentary hour. Adults who reported fewer breaks per sedentary hour (25th percentile < 2 n/day) had higher levels of AASI, awake and sleep PP.
In a medium-sized sample of adult attenders of community clinics our data showed that it seems to be important to avoid prolonged uninterrupted periods of sedentary time.
动脉僵硬度是动脉粥样硬化和心血管疾病发展的一个促成因素。本研究的目的是分析西班牙成年人群中久坐行为与动脉僵硬度之间的关系。
这项横断面研究纳入了1365名属于EVIDENT项目的受试者。使用ActiGraph加速度计客观测量7天内的身体活动和久坐行为。连续10分钟的阈值用于估计每日久坐时间≥10分钟的时段。久坐时间的每次中断（计数/分钟≥100）被视为一次休息。使用B-pro设备通过以下指标评估动脉僵硬度：桡动脉增强指数（rAIx）、动态动脉僵硬度指数（AASI）以及中心和外周脉压（PP）。
我们发现中心和外周脉压（诊室、24小时、清醒和睡眠时的脉压）与总久坐时间之间呈正相关。这些动脉僵硬度参数也与久坐时间≥10分钟的时段有关。然而，在调整中度至剧烈身体活动（MVPA）和每久坐小时的休息次数后，这两种情况下的相关性均消失。每久坐小时休息次数较少（第25百分位数<2次/天）的成年人，其AASI、清醒和睡眠时脉压水平较高。
在社区诊所成年就诊者构成的一个中等规模样本中，我们的数据表明，避免长时间连续久坐似乎很重要。
