Shao Jingxin, Xuan Mingjun, Si Tieyan, Dai Luru, He Qiang
State Key Laboratory of Robotics and System (HIT), Micro/Nanotechnology Research Center, Harbin Institute of Technology, Harbin 150080, China.
Nanoscale. 2015 Dec 7;7(45):19092-8. doi: 10.1039/c5nr06350g. Epub 2015 Nov 2.
Seeking safe and effective water-soluble drug carriers is of great significance in nanomedicine. To achieve this goal, we present a novel drug delivery system based on biointerfacing hollow polymeric microcapsules for effectively encapsulating water-soluble antitumor drug and gold nanorod (GNR) functionalization for triggered release of therapeutic drugs on-demand using low power near-infrared (NIR) radiation. The surface of polymeric microcapsules is covered with fluidic lipid bilayers to decrease the permeability of the wall of polymeric capsules. The temperature increase upon NIR illumination deconstructs the structure of the lipid membrane and polyelectrolyte multilayers, which in turn results in the rapid release of encapsulated water-soluble drug. In vivo antitumor tests demonstrate that this microcapsule has the effective ability of inhibiting tumor growth and preventing metastases. Real time in vivo fluorescence imaging results confirm that capsules can be excreted gradually from the animal body which in turn demonstrates the biocompatibility and biodegradation of these biointerfacing GNR-microcapsules. This intelligent system provides a novel anticancer platform with the advantages of controlled release, biological friendliness and credible biosafety.
在纳米医学中，寻找安全有效的水溶性药物载体具有重要意义。为实现这一目标，我们提出了一种基于生物界面空心聚合物微胶囊的新型药物递送系统，用于有效封装水溶性抗肿瘤药物，并通过金纳米棒（GNR）功能化，利用低功率近红外（NIR）辐射按需触发治疗药物的释放。聚合物微胶囊的表面覆盖有流体脂质双层，以降低聚合物胶囊壁的渗透性。近红外照射引起的温度升高会破坏脂质膜和聚电解质多层膜的结构，进而导致封装的水溶性药物快速释放。体内抗肿瘤试验表明，这种微胶囊具有抑制肿瘤生长和预防转移的有效能力。实时体内荧光成像结果证实，微胶囊可以从动物体内逐渐排出，这反过来证明了这些生物界面GNR微胶囊的生物相容性和生物降解性。这种智能系统提供了一个新型的抗癌平台，具有控释、生物友好性和可靠的生物安全性等优点。
