Maiti Debabrata, Saha Arindam, Devi Parukuttyamma Sujatha
Nano-Structured Materials Division, CSIR-Central Glass and Ceramic Research Institute, Kolkata 700032, India.
Phys Chem Chem Phys. 2016 Jan 21;18(3):1439-50. doi: 10.1039/c5cp05840f. Epub 2015 Nov 2.
Multifunctional ZnFe2O4 nanoparticles were successfully synthesized via thermolysis of Fe-oleate and Zn-oleate precursors. Monodisperse, single phase ZnFe2O4 nanoparticles with an average particle size of ∼22 nm, exhibiting green emission (λmax∼ 480 nm) and ferromagnetism at room temperature (saturation magnetization of 48.46 emu gm(-1)) have been formed by this novel approach. By appropriate surface functionalization, these materials have been converted into smart carriers of hydrophobic (water insoluble) drug molecule-curcumin and hydrophilic (water soluble) drug molecule-daunorubicin. The in vitro cytotoxicity of both the hydrophobic and hydrophilic drug loaded ZnFe2O4 nanoparticles was studied using the conventional MTT assay which revealed that the drug loaded nanoparticles induce significant death of the carcinoma cells (HeLa). Interestingly, this appears to be a significant development towards the capability of surface functionalized multifunctional ZnFe2O4 nanoparticles as carriers for both water soluble and insoluble drugs for anti-cancer therapy.
通过油酸铁和油酸锌前驱体的热分解成功合成了多功能ZnFe2O4纳米颗粒。通过这种新颖的方法形成了平均粒径约为22 nm的单分散单相ZnFe2O4纳米颗粒，其在室温下呈现绿色发射（λmax∼480 nm）和铁磁性（饱和磁化强度为48.46 emu gm(-1)）。通过适当的表面功能化，这些材料已被转化为疏水性（水不溶性）药物分子姜黄素和亲水性（水溶性）药物分子柔红霉素的智能载体。使用传统的MTT法研究了负载疏水性和亲水性药物的ZnFe2O4纳米颗粒的体外细胞毒性，结果表明负载药物的纳米颗粒可诱导癌细胞（HeLa）显著死亡。有趣的是，这似乎是朝着表面功能化多功能ZnFe2O4纳米颗粒作为水溶性和不溶性抗癌药物载体的能力迈出的重要一步。
