高剂量抗菌药物对从囊性纤维化患者中分离出的无色杆菌属生物膜生长的影响。
Effect of High-Dose Antimicrobials on Biofilm Growth of Achromobacter Species Isolated from Cystic Fibrosis Patients.
作者信息
Tom Sean K, Yau Yvonne C W, Beaudoin Trevor, LiPuma John J, Waters Valerie
机构信息
Division of Infectious Diseases, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
Division of Microbiology, Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
出版信息
Antimicrob Agents Chemother. 2015 Nov 2;60(1):650-2. doi: 10.1128/AAC.02240-15. Print 2016 Jan.
Abstract
MICs and biofilm inhibitory concentrations (BICs) were measured for 68 cystic fibrosis (CF) Achromobacter isolates for amikacin, aztreonam, colistin, levofloxacin, and tobramycin. With the exception of colistin and levofloxacin, the remaining antibiotics had MIC90s, BICs at which 50% of the isolates were susceptible (BIC50s), and BICs at which 90% of the isolates were susceptible (BIC90s) equal to or above the highest concentrations tested. In a biofilm model, tobramycin was able to significantly increase killing of bacterial cells compared to controls, for intermediate-resistant strains only, at concentrations of 1,000 and 2,000 μg/ml.
摘要
对68株囊性纤维化（CF）不动杆菌分离株测定了阿米卡星、氨曲南、黏菌素、左氧氟沙星和妥布霉素的最低抑菌浓度（MIC）和生物膜抑制浓度（BIC）。除黏菌素和左氧氟沙星外，其余抗生素的MIC90、50%分离株敏感时的BIC（BIC50）以及90%分离株敏感时的BIC（BIC90）均等于或高于所测试的最高浓度。在生物膜模型中，仅对于中度耐药菌株，在浓度为1000和2000μg/ml时，与对照相比，妥布霉素能够显著增强对细菌细胞的杀灭作用。
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