木糖氧化无色杆菌固有氨基糖苷类耐药性归因于 AxyXY-OprZ，一种 RND 型多药外排泵。
Innate aminoglycoside resistance of Achromobacter xylosoxidans is due to AxyXY-OprZ, an RND-type multidrug efflux pump.
机构信息
Department of Bacteriology, University Hospital of Dijon, Dijon, France.
出版信息
Antimicrob Agents Chemother. 2013 Jan;57(1):603-5. doi: 10.1128/AAC.01243-12. Epub 2012 Oct 22.
Abstract
Achromobacter xylosoxidans is an innately multidrug-resistant pathogen which is emerging in cystic fibrosis (CF) patients. We characterized a new resistance-nodulation-cell division (RND)-type multidrug efflux pump, AxyXY-OprZ. This system is responsible for the intrinsic high-level resistance of A. xylosoxidans to aminoglycosides (tobramycin, amikacin, and gentamicin). Furthermore, it can extrude cefepime, carbapenems, some fluoroquinolones, tetracyclines, and erythromycin. Some of the AxyXY-OprZ substrates are major components widely used to treat pulmonary infections in CF patients.
摘要
木糖氧化无色杆菌是一种固有多重耐药病原体，在囊性纤维化（CF）患者中逐渐出现。我们对一种新型的耐药性结节性分裂（RND）型多药外排泵 AxyXY-OprZ 进行了特征描述。该系统负责木糖氧化无色杆菌对氨基糖苷类（妥布霉素、阿米卡星和庆大霉素）的固有高水平耐药性。此外，它还可以外排头孢吡肟、碳青霉烯类、一些氟喹诺酮类、四环素类和红霉素。AxyXY-OprZ 的一些底物是治疗 CF 患者肺部感染的主要广泛使用的成分。
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