光滑念珠菌膀胱炎患者在卡泊芬净与氟胞嘧啶联合治疗期间获得氟胞嘧啶耐药性。
Acquired Flucytosine Resistance during Combination Therapy with Caspofungin and Flucytosine for Candida glabrata Cystitis.
作者信息
Charlier Caroline, El Sissy Carine, Bachelier-Bassi Sophie, Scemla Anne, Quesne Gilles, Sitterlé Emilie, Legendre Christophe, Lortholary Olivier, Bougnoux Marie-Elisabeth
机构信息
Université Paris Descartes Sorbonne Paris Cité, Service de Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Institut Imagine, Paris, France
Université Paris Descartes Sorbonne Paris Cité, Service de Microbiologie Clinique, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
出版信息
Antimicrob Agents Chemother. 2015 Nov 2;60(1):662-5. doi: 10.1128/AAC.02265-15. Print 2016 Jan.
Abstract
Treatment of Candida glabrata cystitis remains a therapeutic challenge, and an antifungal combination using flucytosine is one option. We describe two patients with refractory C. glabrata cystitis who failed flucytosine combined with caspofungin with early-acquired high-level resistance to flucytosine due to nonsense mutations in the FUR1 gene. Rapidly acquired flucytosine resistance with microbiological failure should discourage combination of caspofungin and flucytosine during urinary candidiasis.
摘要
光滑念珠菌膀胱炎的治疗仍然是一项治疗挑战，使用氟胞嘧啶的抗真菌联合治疗是一种选择。我们描述了两名难治性光滑念珠菌膀胱炎患者，他们在接受氟胞嘧啶联合卡泊芬净治疗时失败，由于FUR1基因的无义突变，早期获得了对氟胞嘧啶的高水平耐药性。在泌尿系统念珠菌病期间，快速获得氟胞嘧啶耐药性并伴有微生物学治疗失败，不应采用卡泊芬净和氟胞嘧啶联合治疗。
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本文引用的文献
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Natural insertions in rice commonly form tandem duplications indicative of patch-mediated double-strand break induction and repair.水稻中的自然插入通常形成串联重复序列，表明是通过斑点介导的双链断裂诱导和修复。
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The Candida genome database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrata.念珠菌基因组数据库整合了多个念珠菌物种：多物种搜索和分析工具，以及针对白念珠菌和光滑念珠菌的经过精心整理的基因和蛋白质信息。
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Pharmacodynamics of echinocandins against Candida glabrata: requirement for dosage escalation to achieve maximal antifungal activity in neutropenic hosts.棘白菌素类药物对光滑念珠菌的药效学：中性粒细胞减少宿主需加大剂量以达到最大抗真菌活性。
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