Charlier Caroline, El Sissy Carine, Bachelier-Bassi Sophie, Scemla Anne, Quesne Gilles, Sitterlé Emilie, Legendre Christophe, Lortholary Olivier, Bougnoux Marie-Elisabeth
Université Paris Descartes Sorbonne Paris Cité, Service de Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Institut Imagine, Paris, France
Université Paris Descartes Sorbonne Paris Cité, Service de Microbiologie Clinique, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Antimicrob Agents Chemother. 2015 Nov 2;60(1):662-5. doi: 10.1128/AAC.02265-15. Print 2016 Jan.
Treatment of Candida glabrata cystitis remains a therapeutic challenge, and an antifungal combination using flucytosine is one option. We describe two patients with refractory C. glabrata cystitis who failed flucytosine combined with caspofungin with early-acquired high-level resistance to flucytosine due to nonsense mutations in the FUR1 gene. Rapidly acquired flucytosine resistance with microbiological failure should discourage combination of caspofungin and flucytosine during urinary candidiasis.
光滑念珠菌膀胱炎的治疗仍然是一项治疗挑战，使用氟胞嘧啶的抗真菌联合治疗是一种选择。我们描述了两名难治性光滑念珠菌膀胱炎患者，他们在接受氟胞嘧啶联合卡泊芬净治疗时失败，由于FUR1基因的无义突变，早期获得了对氟胞嘧啶的高水平耐药性。在泌尿系统念珠菌病期间，快速获得氟胞嘧啶耐药性并伴有微生物学治疗失败，不应采用卡泊芬净和氟胞嘧啶联合治疗。
