一例由耐棘白菌素引起的血流感染合并尿路感染致死病例的药物分析
Drug analysis of a fatal case of bloodstream infection combined with urinary tract infection due to echinocandin-resistant .
作者信息
Wang Linling, Wang Liangfen, Liu Man, Ou Yaqing, Yang Liang, Chen Rong
机构信息
Department of Pharmacy, Genertec Medical 363 Hospital, Chengdu, China.
出版信息
IDCases. 2025 May 9;40:e02261. doi: 10.1016/j.idcr.2025.e02261. eCollection 2025.
When a urinary tract infection (UTI) progresses to a bloodstream infection (BSI), the choice of therapeutic drugs should consider their effectiveness against both BSI and UTI. exhibits strong resistance to antifungal drugs, making the treatment of BSI combined with UTI caused by this pathogen challenging. We report a fatal case of BSI combined with UTI caused by echinocandin-resistant in a 68-year-old female patient. The patient was treated with fluconazole, caspofungin, voriconazole, amphotericin B, and 5-flucytosine throughout the treatment process, but the infection was not controlled in the end. We analyzed the shortcomings in the medication process to provide some references for physicians in clinical treatment.
当尿路感染（UTI）进展为血流感染（BSI）时，治疗药物的选择应考虑其对BSI和UTI的有效性。 对抗真菌药物表现出强烈耐药性，使得由该病原体引起的BSI合并UTI的治疗具有挑战性。我们报告了一例68岁女性患者因对棘白菌素耐药的 引起的BSI合并UTI的致命病例。在整个治疗过程中，患者接受了氟康唑、卡泊芬净、伏立康唑、两性霉素B和5-氟胞嘧啶治疗，但最终感染未得到控制。我们分析了用药过程中的不足之处，为临床治疗中的医生提供一些参考。
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