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诺琳（Norine）是一个致力于非核糖体肽的知识库，现在它向众包开放。

Norine, the knowledgebase dedicated to non-ribosomal peptides, is now open to crowdsourcing.

作者信息

Flissi Areski, Dufresne Yoann, Michalik Juraj, Tonon Laurie, Janot Stéphane, Noé Laurent, Jacques Philippe, Leclère Valérie, Pupin Maude

机构信息

University of Lille, CRIStAL, UMR CNRS 9189, cité scientifique-bat M3ext, 59650 Villeneuve d'Ascq, France Inria Lille Nord Europe, Bonsai team, Parc scientifique de la Haute Borne, 40, avenue Halley-Bt A, 59650 Villeneuve d'Ascq, France

University of Lille, CRIStAL, UMR CNRS 9189, cité scientifique-bat M3ext, 59650 Villeneuve d'Ascq, France Inria Lille Nord Europe, Bonsai team, Parc scientifique de la Haute Borne, 40, avenue Halley-Bt A, 59650 Villeneuve d'Ascq, France.

出版信息

Nucleic Acids Res. 2016 Jan 4;44(D1):D1113-8. doi: 10.1093/nar/gkv1143. Epub 2015 Nov 2.

DOI:10.1093/nar/gkv1143
PMID:26527733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4702827/
Abstract

Since its creation in 2006, Norine remains the unique knowledgebase dedicated to non-ribosomal peptides (NRPs). These secondary metabolites, produced by bacteria and fungi, harbor diverse interesting biological activities (such as antibiotic, antitumor, siderophore or surfactant) directly related to the diversity of their structures. The Norine team goal is to collect the NRPs and provide tools to analyze them efficiently. We have developed a user-friendly interface and dedicated tools to provide a complete bioinformatics platform. The knowledgebase gathers abundant and valuable annotations on more than 1100 NRPs. To increase the quantity of described NRPs and improve the quality of associated annotations, we are now opening Norine to crowdsourcing. We believe that contributors from the scientific community are the best experts to annotate the NRPs they work on. We have developed MyNorine to facilitate the submission of new NRPs or modifications of stored ones. This article presents MyNorine and other novelties of Norine interface released since the first publication. Norine is freely accessible from the following URL: http://bioinfo.lifl.fr/NRP.

摘要

自2006年创建以来，Norine仍然是唯一专注于非核糖体肽（NRP）的知识库。这些由细菌和真菌产生的次生代谢产物具有多种有趣的生物活性（如抗生素、抗肿瘤、铁载体或表面活性剂），这些活性与它们结构的多样性直接相关。Norine团队的目标是收集NRP并提供有效分析它们的工具。我们开发了一个用户友好的界面和专用工具，以提供一个完整的生物信息学平台。该知识库收集了关于1100多种NRP的丰富而有价值的注释。为了增加所描述的NRP数量并提高相关注释的质量，我们现在向众包开放Norine。我们相信科学界的贡献者是注释他们所研究的NRP的最佳专家。我们开发了MyNorine来方便新NRP的提交或对已存储NRP的修改。本文介绍了MyNorine以及自首次发表以来Norine界面的其他新功能。可通过以下网址免费访问Norine：http://bioinfo.lifl.fr/NRP 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9027/4702827/35b4ee6c9394/gkv1143fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9027/4702827/ac1d982eb378/gkv1143fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9027/4702827/bc0ba1462df6/gkv1143fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9027/4702827/35b4ee6c9394/gkv1143fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9027/4702827/ac1d982eb378/gkv1143fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9027/4702827/bc0ba1462df6/gkv1143fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9027/4702827/35b4ee6c9394/gkv1143fig3.jpg

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