David Liliana, Babin Alexandru, Picos Alina, Dumitrascu Dan Lucian
2nd Medical Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Nicolae Testemitanu University of Medicine and Pharmacy, Kishinev, Moldova.
Clujul Med. 2014;87(3):163-5. doi: 10.15386/cjmed-303. Epub 2014 Aug 5.
Small intestinal bacterial overgrowth is encountered in bowel disorders, including irritable bowel symptoms. Low degrees of inflammation have been recently reported in the irritable bowel syndrome. We looked for the association between intestinal inflammation and small intestinal bacterial overgrowth in irritable bowel syndrome.
Small intestinal bacterial overgrowth was assessed by the H2 glucose breath test in 90 consecutive patients with irritable bowel syndrome. A check-up of the oral cavity was carried out before the breath testing. Further on, the patients were classified into two groups, positive and negative, at the breath test. Then they were tested for intestinal inflammation with a fecal test for calprotectin. We used a semiquantitative test for this study. Both groups were compared for the association of intestinal inflammation with small intestinal bacterial overgrowth.
A number of 24/90 (26.7%) patients with irritable bowel syndrome had small intestinal bacterial overgrowth. A positive test for intestinal inflammation was significantly more frequent in patients with irritable bowel syndrome and small intestinal bacterial overgrowth (chi(2): p<0.05).
Small intestinal bacterial overgrowth is present in almost one quarter of patients with irritable bowel syndrome. It is significantly associated with intestinal inflammation.
小肠细菌过度生长在包括肠易激症状在内的肠道疾病中较为常见。最近有报道称肠易激综合征存在低度炎症。我们探寻肠易激综合征中肠道炎症与小肠细菌过度生长之间的关联。
对90例连续性肠易激综合征患者采用氢气葡萄糖呼气试验评估小肠细菌过度生长情况。在呼气试验前对口腔进行检查。此外，根据呼气试验结果将患者分为阳性和阴性两组。然后通过粪便钙卫蛋白检测对患者进行肠道炎症检测。本研究采用半定量检测方法。比较两组肠道炎症与小肠细菌过度生长之间的关联。
90例肠易激综合征患者中有24例（26.7%）存在小肠细菌过度生长。肠易激综合征合并小肠细菌过度生长的患者肠道炎症检测呈阳性的频率显著更高（卡方检验：p<0.05）。
近四分之一的肠易激综合征患者存在小肠细菌过度生长。它与肠道炎症显著相关。
