Hong Mengyu, Cheng Lu, Liu Yanan, Wu Zufang, Zhang Peng, Zhang Xin
Department of Food Science and Engineering, Ningbo University, Ningbo, China.
Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick, NJ, United States.
Front Microbiol. 2022 Mar 25;13:823902. doi: 10.3389/fmicb.2022.823902. eCollection 2022.
The number of hydroxyl groups and existence of characteristic structural groups in tea polyphenols (TP) make them have antioxidant activity, which gives TP anti-inflammatory effects, toward protecting the intestinal flora and brain neurons. Host-associated microbial metabolites are emerging as dominant modifiers of the central nervous system. As yet, the investigations on host-microbiota crosstalking remain challenging, studies focusing on metabolites such as serotonin, short-chain fatty acids, and others have pinpointed multiple actionable signaling pathways relevant to host health. However, there are still complexities and apparent limitations inherent in transforming complex human diseases to corresponding animal models. Here, we choose to discuss several intestinal metabolites with research value, as crucial areas for assessing TP-mediated chronic brain diseases interactions with microbial.
茶多酚（TP）中的羟基数量和特征结构基团的存在使其具有抗氧化活性，这赋予了TP抗炎作用，有助于保护肠道菌群和脑神经元。宿主相关的微生物代谢产物正成为中枢神经系统的主要调节因子。迄今为止，对宿主-微生物群相互作用的研究仍然具有挑战性，针对血清素、短链脂肪酸等代谢产物的研究已经确定了多个与宿主健康相关的可操作信号通路。然而，将复杂的人类疾病转化为相应的动物模型仍存在固有的复杂性和明显的局限性。在此，我们选择讨论几种具有研究价值的肠道代谢产物，将其作为评估TP介导的慢性脑部疾病与微生物相互作用的关键领域。
