慢性肾脏病中的维生素 K。
Vitamin K in Chronic Kidney Disease.
机构信息
Renal Division, Department of Health Sciences, University of Milan, 20142 Milan, Italy.
Renal Research Laboratory, Department of Nephrology, Dialysis and Renal Transplant, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico & Fondazione D'Amico per la Ricerca sulle Malattie Renali, 20122 Milan, Italy.
出版信息
Nutrients. 2019 Jan 14;11(1):168. doi: 10.3390/nu11010168.
Abstract
Vitamin K is a composite term referring to a group of fat-soluble vitamins that function as a cofactor for the enzyme γ-glutamyl carboxylase (GGCX), which activates a number of vitamin K-dependent proteins (VKDPs) involved in haemostasis and vascular and bone health. Accumulating evidence demonstrates that chronic kidney disease (CKD) patients suffer from subclinical vitamin K deficiency, suggesting that this represents a population at risk for the biological consequences of poor vitamin K status. This deficiency might be caused by exhaustion of vitamin K due to its high requirements by vitamin K-dependent proteins to inhibit calcification.
摘要
维生素 K 是一个复合术语，指的是一组脂溶性维生素，作为 γ-谷氨酰羧化酶（GGCX）的辅助因子发挥作用，该酶激活了许多参与止血、血管和骨骼健康的维生素 K 依赖性蛋白（VKDPs）。越来越多的证据表明，慢性肾脏病（CKD）患者存在亚临床维生素 K 缺乏，这表明他们是维生素 K 状态不良的生物学后果的高危人群。这种缺乏可能是由于维生素 K 依赖性蛋白抑制钙化的高需求导致维生素 K 耗尽引起的。
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