Renal Division, Department of Health Sciences, University of Milan, 20142 Milan, Italy.
Renal Research Laboratory, Department of Nephrology, Dialysis and Renal Transplant, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico & Fondazione D'Amico per la Ricerca sulle Malattie Renali, 20122 Milan, Italy.
Nutrients. 2019 Jan 14;11(1):168. doi: 10.3390/nu11010168.
Vitamin K is a composite term referring to a group of fat-soluble vitamins that function as a cofactor for the enzyme γ-glutamyl carboxylase (GGCX), which activates a number of vitamin K-dependent proteins (VKDPs) involved in haemostasis and vascular and bone health. Accumulating evidence demonstrates that chronic kidney disease (CKD) patients suffer from subclinical vitamin K deficiency, suggesting that this represents a population at risk for the biological consequences of poor vitamin K status. This deficiency might be caused by exhaustion of vitamin K due to its high requirements by vitamin K-dependent proteins to inhibit calcification.
维生素 K 是一个复合术语,指的是一组脂溶性维生素,作为 γ-谷氨酰羧化酶(GGCX)的辅助因子发挥作用,该酶激活了许多参与止血、血管和骨骼健康的维生素 K 依赖性蛋白(VKDPs)。越来越多的证据表明,慢性肾脏病(CKD)患者存在亚临床维生素 K 缺乏,这表明他们是维生素 K 状态不良的生物学后果的高危人群。这种缺乏可能是由于维生素 K 依赖性蛋白抑制钙化的高需求导致维生素 K 耗尽引起的。