Gonzalez-Buritica H, Khamashita M A, Hughes G R
Research Unit, Rayne Institute, St Thomas's Hospital, London.
Ann Rheum Dis. 1989 Apr;48(4):267-9. doi: 10.1136/ard.48.4.267.
The activation of phospholipase A2 is believed to have an important role in the inflammatory process owing to its induction of eicosanoids, platelet activating factor, and other mediators. Soluble phospholipase A2 has been associated with exudates in different inflammatory conditions. In this review the general physiology and control of this enzyme and, in particular, the most recent findings on human synovial fluid phospholipase A2s are discussed.
由于磷脂酶A2可诱导类花生酸、血小板活化因子及其他介质的产生,因此其激活在炎症过程中被认为具有重要作用。可溶性磷脂酶A2与不同炎症状态下的渗出物有关。在本综述中,我们将讨论该酶的一般生理学和调控,特别是关于人滑液磷脂酶A2的最新研究结果。