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类风湿性和非类风湿性滑膜衬里在非增殖性器官培养中花生四烯酸环氧化酶产物的合成。

Synthesis of arachidonate cyclo-oxygenase products by rheumatoid and nonrheumatoid synovial lining in nonproliferative organ culture.

作者信息

Salmon J A, Higgs G A, Vane J R, Bitensky L, Chayen J, Henderson B, Cashman B

出版信息

Ann Rheum Dis. 1983 Feb;42(1):36-9. doi: 10.1136/ard.42.1.36.

DOI:10.1136/ard.42.1.36
PMID:6402992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1001056/
Abstract

Specimens of human rheumatoid and nonrheumatoid synovial lining were maintained in nonproliferative organ culture for 20 hours. The culture fluids were then assayed for prostaglandin E(2) (PGE(2)), thromboxane B(2) (TXB(2)), and 6-keto-prostaglandin F(1alpha) (6-keto-PGF(1alpha)) by specific radioimmunoassay. The presence of each of these substances was confirmed by gas chromatography and mass spectrometry. Rheumatoid tissue produced significantly more of each cyclo-oxygenase product than nonrheumatoid tissue.

摘要

将人类类风湿性和非类风湿性滑膜衬里标本在非增殖性器官培养中维持20小时。然后通过特异性放射免疫分析法检测培养液中的前列腺素E(2)（PGE(2)）、血栓素B(2)（TXB(2)）和6-酮-前列腺素F(1α)（6-酮-PGF(1α)）。这些物质中的每一种的存在均通过气相色谱法和质谱法得以证实。类风湿组织产生的每种环氧化酶产物均明显多于非类风湿组织。

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The culture of mature organs in a synthetic medium.在合成培养基中对成熟器官进行培养。
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PGE2, PGF2 alpha, and TXB2 biosynthesis by human rheumatoid synovia.人类类风湿性滑膜组织中前列腺素E2、前列腺素F2α和血栓素B2的生物合成
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Prostaglandin synthetase activity from human rheumatoid synovial microsomes. Effect of 'aspirin-like' drug therapy.人类风湿性滑膜微粒体中的前列腺素合成酶活性。“阿司匹林样”药物治疗的影响。
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Chemotactic activity of thromboxane B2, prostaglandins and their metabolites for polymorphonuclear leucocytes.血栓素B2、前列腺素及其代谢产物对多形核白细胞的趋化活性。
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