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[脑静脉窦血栓形成:流行病学、临床特征、影像学及预后]

[Cerebral venous sinus thrombosis: Epidemiology, clinical characteristics, imaging and prognosis].

作者信息

Zuluaga María Isabel, Massaro Mónica, Franco César Augusto

机构信息

Universidad CES, Instituto Neurológico de Colombia, Medellín, Colombia.

Investigación, Docencia y Epidemiología, Instituto Neurológico de Colombia, Medellín, Colombia.

出版信息

Biomedica. 2015 Apr-Jun;35(2):196-203. doi: 10.1590/S0120-41572015000200007.

DOI:10.1590/S0120-41572015000200007
PMID:26535541
Abstract

INTRODUCTION

Cerebral venous sinus thrombosis represents 0.5 - 1% of all cerebrovascular diseases.

OBJECTIVE

The aim of this study was to determine the epidemiological, clinical, and imaging features of the disease, as well as the outcomes of patients with cerebral venous sinus thrombosis, and to explore the characteristics associated with unfavorable patient outcomes.

MATERIALS AND METHODS

In this cross-sectional, retrospective study, the medical records of 37 patients with cerebral venous sinus thrombosis were analyzed.

RESULTS

Eighty-six percent of the patients were women, and the mean patient age was 41 years. The most frequently reported symptom was headache (86.5%); headache was the single presenting symptom in 40.5% of the patients. Sixty-eight percent of the patients had at least one risk factor, the most frequent of which was obesity (24.3%). A total of 43.2% of the patients had no focal neurological findings. The most common finding on computerized tomography (CT) was hyperdense venous sinuses; on Magnetic Resonance Imaging (MRI), the most common finding was venous infarction. On average, 2.27±1.3 sinuses were involved; most frequently, the transverse venous sinuses were affected. The average hospital stay was 7.8±3.6 days. At hospital discharge, the outcomes were favorable in 92% of the patients, and the mortality rate was 5.4%.

CONCLUSIONS

Cerebral venous sinus thrombosis is a different type of cerebrovascular disorder, with distinct epidemiology, risk factors, clinical presentations and functional outcomes. The diagnosis is based on clinical suspicion because of the unspecific clinical presentation of the disease.

摘要

引言

脑静脉窦血栓形成占所有脑血管疾病的0.5 - 1%。

目的

本研究的目的是确定该疾病的流行病学、临床和影像学特征,以及脑静脉窦血栓形成患者的预后,并探讨与患者不良预后相关的特征。

材料与方法

在这项横断面回顾性研究中,分析了37例脑静脉窦血栓形成患者的病历。

结果

86%的患者为女性,患者平均年龄为41岁。最常报告的症状是头痛(86.5%);40.5%的患者仅以头痛为首发症状。68%的患者至少有一个危险因素,其中最常见的是肥胖(24.3%)。共有43.2%的患者没有局灶性神经学表现。计算机断层扫描(CT)最常见的表现是静脉窦高密度影;磁共振成像(MRI)最常见的表现是静脉梗死。平均累及2.27±1.3个静脉窦;最常受累的是横窦。平均住院时间为7.8±3.6天。出院时,92%的患者预后良好,死亡率为5.4%。

结论

脑静脉窦血栓形成是一种不同类型的脑血管疾病,具有独特的流行病学、危险因素、临床表现和功能预后。由于该疾病临床表现不具特异性,诊断基于临床怀疑。

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