Lee Yuan-Ti, Nfor Oswald Ndi, Tantoh Disline Manli, Huang Jing-Yang, Ku Wen-Yuan, Hsu Shu-Yi, Ko Pei-Chieh, Hung Hung-Chang, Jan Cheng-Feng, Liaw Yung-Po
Division of Infectious Diseases, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan, ROC.
School of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC.
PLoS One. 2015 Nov 4;10(11):e0142254. doi: 10.1371/journal.pone.0142254. eCollection 2015.
This study aimed to investigate the association between herpes zoster (HZ) and human immunodeficiency virus (HIV). Data were retrieved from the Longitudinal Health Insurance Databases (LHID 2005 and 2010), Taiwan. The International Classification of Diseases, 9th Revision, Clinical Modification [ICD-9-CM] codes were used to identify Hz from 2001-2004. Identification of HIV infection was from 2005-2010. The hazard ratios of HIV among herpes zoster infected and non-herpes zoster infected patients were estimated using multiple Cox proportional hazard model. In general, 19685 participants were identified with Hz. The HIV incidence rates (per 104 person-months) in herpes zoster infected and non-infected patients were 0.191(95% CI 0.130-0.280) and 0.079 (95% CI 0.074-0.084), respectively while the hazard ratio (HR) of HIV among infected individuals was 3.518 (95% CI 2.375-5.211). This study concludes that herpes zoster could be considered as a predictor of HIV infection especially among Asian populations, hence it is vital to test herpes zoster infected individuals for HIV antibodies.
本研究旨在调查带状疱疹（HZ）与人类免疫缺陷病毒（HIV）之间的关联。数据取自台湾纵向健康保险数据库（LHID 2005和2010）。使用国际疾病分类第九版临床修订本[ICD-9-CM]编码从2001年至2004年识别带状疱疹。HIV感染的识别时间为2005年至2010年。使用多重Cox比例风险模型估计带状疱疹感染患者和未感染带状疱疹患者中HIV的风险比。总体而言，有19685名参与者被确诊患有带状疱疹。带状疱疹感染患者和未感染患者的HIV发病率（每104人月）分别为0.191（95%可信区间0.130 - 0.280）和0.079（95%可信区间0.074 - 0.084），而感染个体中HIV的风险比（HR）为3.518（95%可信区间2.375 - 5.211）。本研究得出结论，带状疱疹可被视为HIV感染的一个预测指标，尤其是在亚洲人群中，因此对带状疱疹感染个体进行HIV抗体检测至关重要。
