Du Y, Gao L, Zhang K, Wang J
Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
Genet Mol Res. 2015 Oct 27;14(4):13236-46. doi: 10.4238/2015.October.26.20.
The human IL6 [interleukin 6 (interferon, beta 2)] gene encodes IL-6, a cytokine which not only plays regulatory roles in inflammation, but may be also involved in the progression of cancer. Rs1800796 is a single nucleotide polymorphism (SNP) in the promoter region of IL6, and is associated with IL-6 production. A number of studies have been carried out to determine whether this SNP is associated with cancer risk. However, the results are inconsistent due to small sample sizes of individual studies and limited statistical power. Therefore, to evaluate the overall effect on all investigated cancer types, we conducted a meta-analysis by combining all available studies. Nineteen eligible case-control studies including 23,030 subjects (9,985 cases and 13,045 controls) were included for this meta-analysis. Our study demonstrates that rs1800796 is significantly associated with cancer risk in three genetic models (allele G vs allele C, pooled OR = 1.182, P = 0.009; CG + GG vs CC, pooled OR = 1.333, P = 0.006; CG vs CC, pooled OR = 1.323, P = 0.007).Our meta-analysis suggests that polymorphism rs1800796 within the IL6 gene may be a potential risk factor for cancer.
人类白细胞介素6（IL6）基因编码白细胞介素-6（IL-6），它是一种细胞因子，不仅在炎症中发挥调节作用，还可能参与癌症的进展。Rs1800796是IL6启动子区域的一个单核苷酸多态性（SNP），与IL-6的产生相关。已经开展了许多研究来确定该SNP是否与癌症风险相关。然而，由于个别研究的样本量较小且统计效力有限，结果并不一致。因此，为了评估对所有研究的癌症类型的总体影响，我们通过合并所有可用研究进行了一项荟萃分析。本荟萃分析纳入了19项符合条件的病例对照研究，包括23,030名受试者（9,985例病例和13,045名对照）。我们的研究表明，在三种遗传模型中，rs1800796与癌症风险显著相关（等位基因G与等位基因C，合并比值比=1.182，P=0.009；CG+GG与CC，合并比值比=1.333，P=0.006；CG与CC，合并比值比=1.323，P=0.007）。我们的荟萃分析表明，IL6基因内的多态性rs1800796可能是癌症的一个潜在风险因素。
