Turay David, Khan Salma, Diaz Osterman Carlos J, Curtis Matthew P, Khaira Balreet, Neidigh Jonathan W, Mirshahidi Saied, Casiano Carlos A, Wall Nathan R
a Center for Health Disparities & Molecular Medicine , Loma Linda University School of Medicine , Loma Linda , California , USA.
b Department of Basic Science and Division of Biochemistry , Loma Linda University School of Medicine , Loma Linda , California , USA.
Cancer Invest. 2016;34(1):1-11. doi: 10.3109/07357907.2015.1081921. Epub 2015 Nov 4.
Prostate cancer (PCa) remains the most frequently diagnosed male malignancy in Western countries and the second most common cause of male cancer death in the United States. The relatively elevated PCa incidence and mortality among African American men makes this cancer type a challenging health disparity disease. To increase the chance for successful trea tment, earlier detection and prediction of tumor aggress iveness will be important and need to be resolved. This study demonstrates that small membrane-bound vesicles shed from the tumor called exosomes contain ethnically and tumor-specific biomarkers, and could be exploited for their diagnostic and therapeutic potential.
前列腺癌（PCa）仍是西方国家最常被诊断出的男性恶性肿瘤，也是美国男性癌症死亡的第二大常见原因。非裔美国男性中相对较高的前列腺癌发病率和死亡率使这种癌症类型成为一种具有挑战性的健康差距疾病。为了增加成功治疗的机会，肿瘤侵袭性的早期检测和预测将很重要且需要解决。这项研究表明，肿瘤脱落的称为外泌体的小膜结合囊泡含有种族和肿瘤特异性生物标志物，并且可以利用它们的诊断和治疗潜力。
