Luo Huanan, Ma Sijing, Gao Yin, Yan Jing, Hou Jin, Xu Min
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(11):997-1001.
To analyze the therapeutic effect of proton pump inhibitor(PPI) on alleviation of hoarseness symptoms in patients with laryngopharyngeal reflux(LPR).
The LPR outpatients in ENT department of our hospital(60 cases)complained of hoarseness were enrolled in the study from August of 2013 to October of 2014. All of them were randomly divided into group A and B. The individuals in group A (30 cases) taked golden voice capsule to treat for 3 months, while the individuals in group B (30 cases) taked golden voice capsule and omeprazole to treat for 3 months. The data about reflux symptom index (RSI), reflux finding score (RFS) and voice handicap index (VHI)from the first month to the third month after treatment were recorded and compared group A with group B.
The scores of RSI and RFS in patients (60 cases) before treatment were significantly correlated with their VHI (r=0. 823, P<0. 01; r=0. 873, P<0. 01). The score changes of RSI and VHI from the first to the third month after treatment in group B were significantly higher than those in group A (P<0. 01). Meanwhile, the score changes of RFS from the third month after treatment in group B were significantly higher than those in group A (t=8. 307, P<. 01), but the differences were not significant for RFS from the first to the second month after treatment between group A and group B(t=1. 128, P>0. 05; t=0. 376, P> 0. 05).
PPI therapy could significantly alleviate the hoarseness symptom in LPR patients.
分析质子泵抑制剂（PPI）对缓解喉咽反流（LPR）患者声音嘶哑症状的治疗效果。
选取2013年8月至2014年10月在我院耳鼻喉科门诊就诊的60例以声音嘶哑为主要症状的LPR患者纳入研究。将所有患者随机分为A组和B组。A组（30例）服用金嗓散结胶囊治疗3个月，B组（30例）服用金嗓散结胶囊及奥美拉唑治疗3个月。记录治疗后第1个月至第3个月的反流症状指数（RSI）、反流发现评分（RFS）及嗓音障碍指数（VHI）数据，并对A组和B组进行比较。
60例患者治疗前的RSI、RFS评分与VHI均显著相关（r = 0.823，P < 0.01；r = 0.873，P < 0.01）。治疗后第1个月至第3个月，B组RSI及VHI评分变化显著高于A组（P < 0.01）。同时，治疗后第3个月B组RFS评分变化显著高于A组（t = 8.307，P < 0.01），但治疗后第1个月至第2个月A组与B组RFS差异无统计学意义（t = 1.128，P > 0.05；t = 0.376，P > 0.05）。
PPI治疗可显著缓解LPR患者的声音嘶哑症状。
