Li Xiao, Zhang Weidong, Chen Gaojian
Center for Soft Condensed Matter Physics and Interdisciplinary Research, Soochow University, Suzhou, 215006, China.
Methods Mol Biol. 2016;1367:149-55. doi: 10.1007/978-1-4939-3130-9_12.
Glycopolymers with carbohydrate side chains are currently being applied in many fields, with much potential for disease treatment. The shape of glycopolymer-bearing nanoparticles has obvious effects on the nanoparticle-cell interaction and is therefore important for the applications of glycopolymers in biological systems. Here a synthetic approach to prepare non-spherical glycopolymer-coated iron oxide nanoparticles is provided, by combing the convenience of inorganic shape control, catecholic chemistry, and thiol-ene reaction.
带有碳水化合物侧链的糖聚合物目前正在许多领域得到应用，在疾病治疗方面具有很大潜力。带有糖聚合物的纳米颗粒的形状对纳米颗粒与细胞的相互作用有明显影响，因此对于糖聚合物在生物系统中的应用很重要。本文提供了一种合成方法，通过结合无机形状控制、儿茶酚化学和硫醇-烯反应的便利性来制备非球形糖聚合物包覆的氧化铁纳米颗粒。
