糖聚合物基纳米粒子金（I）共轭物的合成方法：新一代治疗剂

Synthetic Approach to Glycopolymer Base Nanoparticle Gold(I) Conjugate: A New Generation of Therapeutic Agents.

作者信息

Adokoh Christian K, Darkwa James, Narain Ravin

机构信息

Department of Chemical and Materials Engineering, University of Alberta, 9107-116 Street, Edmonton, AB, Canada, T6G 2V4.

Department of Chemistry, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, South Africa.

出版信息

Methods Mol Biol. 2016;1367:157-68. doi: 10.1007/978-1-4939-3130-9_13.

DOI:10.1007/978-1-4939-3130-9_13

PMID:26537472

Abstract

Advances in nanotechnology have led to the fabrication of nano-constructs of organic or inorganic origins with well-defined structures, surface properties, and can be made to respond to physical or chemical stimuli. These nano-constructs can provide a shift in the way diagnostic and therapeutic drugs are delivered to achieve target specificity and increased retention of therapeutic doses for considerable improvement in the overall treatment of the tumors. In this case we describe here a synthetic approach to glycopolymer base nanoparticle gold(I) conjugate for cancer therapy.

摘要

纳米技术的进步已促使人们制造出具有明确结构、表面性质且能对物理或化学刺激做出响应的有机或无机来源的纳米结构。这些纳米结构可以改变诊断和治疗药物的递送方式，以实现靶向特异性并提高治疗剂量的保留率，从而显著改善肿瘤的整体治疗效果。在本文中，我们描述了一种用于癌症治疗的基于糖聚合物的纳米金（I）缀合物的合成方法。