Yamada Takako, Iida Tetsuo, Takamine Satoshi, Hayashi Noriko, Okuma Kazuhiro
Matsutani Chemical Industry Co., Ltd., Research & Development.
Shokuhin Eiseigaku Zasshi. 2015;56(5):211-6. doi: 10.3358/shokueishi.56.211.
The safety of rare sugar syrup obtained from high-fructose corn syrup under slightly alkaline conditions was studied. Mutagenicity of rare sugar syrup was assessed by a reverse mutation assay using Salmonella typhimurium and Escherichia coli, and an in vitro chromosomal aberration assay using Chinese hamster lung cell line (CHL/IU). No mutagenicity of rare sugar syrup was detected under these experimental conditions. Oral administration of single dose (15,000 mg/kg) of rare sugar syrup to rats caused no abnormalities, suggesting no adverse effect of rare sugar syrup. In humans, the acute non-effect level of rare sugar syrup for causing diarrhea was estimated as 0.9 g/kg body weight as dry solid base in both males and females.
研究了在微碱性条件下由高果糖玉米糖浆制得的稀有糖浆的安全性。通过使用鼠伤寒沙门氏菌和大肠杆菌的回复突变试验以及使用中国仓鼠肺细胞系（CHL/IU）的体外染色体畸变试验评估了稀有糖浆的致突变性。在这些实验条件下未检测到稀有糖浆的致突变性。给大鼠口服单剂量（15,000 mg/kg）的稀有糖浆未引起异常，表明稀有糖浆无不良影响。在人类中，估计稀有糖浆引起腹泻的急性无作用水平在男性和女性中均为0.9 g/kg体重（以干固体计）。
