克伦普菲林Q和R，两种从软珊瑚克氏肉芝软珊瑚中提取的基于二萜类化合物的新化合物。

Krempfielins Q and R, two new eunicellin-based diterpenoids from the soft coral Cladiella krempfi.

作者信息

Tai Chi-Jen, Chokkalingam Uvarani, Cheng Yang, Shih Shou-Ping, Lu Mei-Chin, Su Jui-Hsin, Hwang Tsong-Long, Sheu Jyh-Horng

机构信息

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.

Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.

出版信息

Int J Mol Sci. 2014 Nov 27;15(12):21865-74. doi: 10.3390/ijms151221865.

DOI:10.3390/ijms151221865

PMID:25437917

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4284682/

Abstract

Two new eunicellin-based diterpenoids, krempfielins Q and R (1 and 2), and one known compound cladieunicellin K (3) have been isolated from a Formosan soft coral Cladiella krempfi. The structures of these two new metabolites were elucidated by extensive spectroscopic analysis. Anti-inflammatory activity of new metabolites to inhibit the superoxide anion generation and elastase release in N-formyl-methionyl-leucyl phenylalanine/cytochalasin B (FMLP/CB)-induced human neutrophil cells and cytotoxicity of both new compounds toward five cancer cell lines were reported.

摘要

从台湾软珊瑚克氏肉芝软珊瑚（Cladiella krempfi）中分离出了两种新的基于海兔毒素的二萜类化合物，克氏肉芝软珊瑚素Q和R（1和2），以及一种已知化合物克拉迪尤尼西林K（3）。通过广泛的光谱分析阐明了这两种新代谢物的结构。报道了新代谢物对N-甲酰甲硫氨酰亮氨酰苯丙氨酸/细胞松弛素B（FMLP/CB）诱导的人中性粒细胞中超氧阴离子生成和弹性蛋白酶释放的抗炎活性，以及这两种新化合物对五种癌细胞系的细胞毒性。